Rho gene expression correlates with tumor invasiveness and metastasis in head and neck cancers

Rho 基因表达与头颈癌的肿瘤侵袭性和转移相关

• 批准号: 18591862
• 负责人: MINETA Hiroyuki
• 金额: $ 2.41万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591862/
• 关键词: head and meek cancer; rho; endostatin; 頭頚部癌; Rho; 上皮間葉組織移行

The research of tumor invasiveness by Snail or Twist shows the mechanism of signal transduction in tumor development. However, few information has been revealed endothelial-messenchymal transduction.We showed that rho gene was associated with tumor progression in head and neck squamous cell carcinomas, but not associated with prognosis. And we reported that endogenous endostatin expression correlated with tumor size and p53 expression, but not lymph node status and prognosis, and that high endostatin expression correlated with high microvessel density in primary tumors. Endogenous endostatin which may be upregulated by p53 gene does not represent antiangiogenic phenotype of the primary tumors.endostatin expression correlated with tumor size and p53 expression, but not lymph node status and prognosis, and that high endostatin expression correlated with high microvessel density in primary tumors. Endogenous endostatin which my be upregulated by p53 gene does not represent antiangiogenic phenotype of the primary tumors.

Snail或Twist对肿瘤侵袭性的研究揭示了肿瘤发生发展中的信号转导机制。然而，关于内皮-间质转导的信息很少。我们发现rho基因与头颈鳞状细胞癌的肿瘤进展相关，但与预后无关。我们报道内源性内皮抑素表达与肿瘤大小和 p53 表达相关，但与淋巴结状态和预后无关，并且高内皮抑素表达与原发肿瘤中高微血管密度相关。可能被p53基因上调的内源性内皮抑素并不代表原发肿瘤的抗血管生成表型。内皮抑素表达与肿瘤大小和p53表达相关，但与淋巴结状态和预后无关，并且高内皮抑素表达与原发肿瘤中高微血管密度相关。被p53基因上调的内源性内皮抑素并不代表原发性肿瘤的抗血管生成表型。

项目成果

Association of SLC26A4 mutations with clinical features and thyroid function in deaf infants with enlarged vestibular aqueduct.

SLC26A4 突变与前庭导水管扩大的聋儿临床特征和甲状腺功能的关联。

• 发表时间: 2006
• 期刊: J Hum Genet 51
• 作者: Iwarsaki S;Tsukamoto K;Usami S;Misawa K;Mizuta K;Mineta H
• 通讯作者: Mineta H

頭頸部癌におけるGalaninとGALR1のプロモーター領域のメチル化と発現について

头颈癌中甘丙肽和GALR1启动子区的甲基化及表达

• 发表时间: 2007
• 作者: T. Higashi;H. Mineta;K. Miura;Seido Takae;Yoichi Kobayyashi;Kazushige Kiguchi.;三澤清など
• 通讯作者: 三澤清など

小児副咽頭間隙膿瘍の1例

小儿咽旁间隙脓肿1例

• 发表时间: 2008
• 期刊: 耳鼻咽喉科・頭頸部外科 80
• 作者: Tsukatani T;Miwa T;Ikeno S;Yagi S;Furukawa M;細川誠二など
• 通讯作者: 細川誠二など

悪性リンパ腫における穿刺吸引細胞診の検討

恶性淋巴瘤细针抽吸细胞学检查

• 发表时间: 2007
• 期刊: 耳鼻咽喉科臨床 100
• 作者: 岩森 正男;他;足守直樹 など
• 通讯作者: 足守直樹 など

GALR1 and Galanin gene methylation and clinico pathological findings in head and neck cancers

头颈癌中 GALR1 和甘丙肽基因甲基化及临床病理结果