Analysis of expression mechanism of endostatin and angiostatin

内皮抑素和血管抑素表达机制分析

• 批准号: 12671659
• 负责人: MINETA Hiroyuki
• 金额: $ 2.24万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671659/
• 关键词: Head and Neck; Angiogenesis; Angiostafin; Endostatin; 頭頚部癌; VEGF

We reported tat endostatin expression correlated with tumor size and p53 expression, but not lymph node status and prognosis, and that high endostatin expression correlated with high microvessel density in the primary tumor. Endogenous endostatin which may be upregulated by p53 gene dices not represent antiangiogenic phenotype of the primary tumor.Endostatin inhibits iNOS activity, in thyroid anapiastic carcinoma, maxillary carcinoma, and lung carcinoma cell lines, 2. Inhibition of iNOS activity by endostatin may cause to antoangiogenesis.We speculate a pathway of antiangiogic function of endostatin fron these results. Endostatin inhibits iNOS activity, leading to decrease of NO production in NOS expressed tumor cells. Loss of NO production may cause to antiangiogenesis through inhibition of VEGF and increase of p53 accumulation.

我们报道了tat内皮抑素表达与肿瘤大小和p53表达相关，但与淋巴结状态和预后无关，并且高内皮抑素表达与原发肿瘤中高微血管密度相关。可能被 p53 基因骰子上调的内源性内皮抑素并不代表原发肿瘤的抗血管生成表型。内皮抑素抑制甲状腺再生癌、上颌癌和肺癌细胞系中的 iNOS 活性，2。内皮抑素对 iNOS 活性的抑制可能导致抗血管生成我们根据这些结果推测内皮抑素的抗血管生成功能的途径。内皮抑素抑制 iNOS 活性，导致表达 NOS 的肿瘤细胞中 NO 的产生减少。 NO 产生的损失可能通过抑制 VEGF 和增加 p53 积累而导致抗血管生成。

项目成果

H.Mineta: "Prognostic value of vascular endothelial growth factor (VEGF) expression in head and neck squamous cell carcinomas"Br J Cancer. 83. 775-781 (2000)

H.Mineta：“头颈鳞状细胞癌中血管内皮生长因子 (VEGF) 表达的预后价值”Br J Cancer。

H.Mineta: "Immunohistochemical analysis of small cell carcinoma in head and neck"Ann Otol Rhinol Laryngol. 110. 76-82 (2001)

H.Mineta：“头颈部小细胞癌的免疫组织化学分析”Ann Otol Rhinol Laryngol。

S. Takebayashi, H. Mineta, T Carely, et al: "Loss of heterozeigosity of 18q chromosome in head and neck cancer cell lines"Cancer Res. 60. 3397-3403 (2000)

S. Takebayashi、H. Mineta、T Carely 等人：“头颈癌细胞系中 18q 染色体杂合性的丢失”Cancer Res。

H. Harada, K Miura, H Mineta, et al: "Soritary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis"Pathol Int. 50. 431-439 (2000)

H. Harada、K Miura、H Mineta 等人：“一名患有复发性喉乳头状瘤病的 40 岁女性肺部孤立性鳞状细胞乳头状瘤”Pathol Int。

K Miura, H Fukuda, H Mineta, et al: "Phosphoglyceride crystal deposition disease"Pathol Int. 50. 992-998 (2000)

K Miura、H Fukuda、H Mineta 等：“磷酸甘油酯晶体沉积病”Pathol Int。