Tissue engineering of the ear

耳组织工程

• 批准号: 12671758
• 负责人: ISOGAI Noritaka
• 金额: $ 1.98万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671758/
• 关键词: Polymer; tissue enginnering; chondrocyte; Tissue engineering

We have developed a model of human ear that can be formed in a tissue engineering manner by seeding chondrocytes onto the 3D polymer which has a shape of human ear.The polymer scaffolds supported : growth of chondrocytes after the models were implanted in athymic nude mice. The constructs in vivo developed through vascularization, formed new cartilage with characteristic gene expression and protein synthesis, and maintained the shape of human ear. As additional studies proceed, this approach will clinically become important.

我们已经开发了一种人耳模型，该模型可以通过将软骨细胞播种到3D聚合物上，该模型可以以组织工程的方式形成，该聚合物具有人耳的形状。支撑的聚合物支架：在模型植入小鼠后软骨细胞的生长。体内构建体是通过血管形成开发的，形成了具有特征性基因表达和蛋白质合成的新软骨，并保持了人耳的形状。随着其他研究的进行，这种方法将在临床上变得重要。

项目成果

磯貝典孝: "Tissue engineeringの発展 骨と軟骨"外科治療. 82(4). 953-963 (2000)

Noritaka Isogai：“组织工程骨和软骨的发展”外科治疗 82(4)。