ELECTROPHY SIOLOGICAL AND MORHPHOLOGICAL STUDIES ON INTERACTION BETWEEN THE CEREBELLAR AND BASAL GANGLIA INPUTS.-ANALYSIS OF INTEGRATION IN THE CEREBRAL CORTEX-

关于小脑和基底神经节输入之间相互作用的电学和形态学研究。-大脑皮层整合分析-

• 批准号: 11680806
• 负责人: YAMAMOTO Tetsuro
• 金额: $ 2.37万
• 依托单位: MIE UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680806/
• 关键词: BASAL GANGLIA; CEREBELLAR NUCLEI; MOTOR CORTEX; INTRACELLULAR RECORDING; INTERACTION; MOTOR CONTROL; MEMBRANE POTENTIAL CHANGES; 膜電位変化

Intracellular recordings and staining were performed from pyramidal neurons of motor cortex and related areas in cats, monkeys and rats to investigate the interaction between the cerebellar and basal ganglia inputs. Experiments were done under pentobarbital anesthesia in in vivo preparations on stimulation of cerebellar nuclei and basal ganglia. To obtain the morphological data, we also used anterograde tract tracing method with various tracers. In the beginning of the project, we tried to record from two neurons simultaneously, but it was rather difficult from technical point of view, so we compared the responsiveness of neurons in the motor cortex and those of premotor areas as well as in vitro preparations.

细胞内记录和染色是从猫，猴子和大鼠的运动皮质和相关区域的锥体神经元中进行的，以研究小脑和基底神经节输入之间的相互作用。在刺激小脑核和基底神经节的体内制剂中，在五核麻醉下进行实验。为了获得形态学数据，我们还使用了带有各种示踪剂的顺行轨迹方法。在项目开始时，我们试图同时从两个神经元中记录，但是从技术角度来看，这很困难，因此我们比较了运动皮质中神经元和前运动前区域以及体外准备的响应性。

项目成果

中野勝磨: "視床の構造:形態面から"Clinical Neuroscience. 18(8). 18-21 (2000)

Katsuma Nakano：“丘脑的结构：从形态学角度”临床神经科学 18(8) (2000)。

Nakano, K.: "Neural circuit and topographic organization of the basal ganglia and related regions."Brain and Development. 22. S5-S16 (2000)

Nakano, K.：“基底神经节及相关区域的神经回路和地形组织。”大脑与发育。

Nakano,K.et al.: "Afferent connections to the ventral striatum from the medial prefrontal cortex (area 25) and the thalamic nuclei in the macaque monkey"Annals of the New York Academy of Sci.. 877. 667-670 (1999)

Nakano, K. 等人：“从内侧前额皮质（区域 25）和猕猴的丘脑核到腹侧纹状体的传入连接”纽约科学院年鉴 877. 667-670（1999 年）

Kumazawa,Y.et al.: "Effects of opioids to facial motoneurons in neonatal rats"Neuroscience Research. Suppl.23. S43 (1999)

Kumazawa，Y.et al.：“阿片类药物对新生大鼠面部运动神经元的影响”神经科学研究。

Kitagawa,F., et al.: "Activity-dependent slow hyerpolarization in cat sensorimotor cortex in vitro."Brain Research. 869. 69-77 (2000)

Kitakawa, F., et al.：“体外猫感觉运动皮层的活动依赖性缓慢超极化。”大脑研究。