Studies on the mechanism to gain monocyte chemotactic capacity of ribosomal protein S19 and its role in coagulum resorption.

核糖体蛋白S19获得单核细胞趋化能力的机制及其在凝血吸收中的作用研究。

• 批准号: 21590441
• 负责人: YAMAMOTO Tetsuro
• 金额: $ 3万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590441/
• 关键词: リボソームタンパク質S19; プロトロンビン; 血液凝固反応; 凝固XIII因子; 血小板; 線溶; Glaドメイン; 血漿タンパク質; ワーファリン; リボソームタンパク質; 単球; 白血球走化因子; C5aレセプター; 凝血塊吸収; S19リボソームタンパク質; 単球走化因子; 血液凝固XIII因子; 細胞性線溶; 血栓症; リボソームタンパク質S19; プロトロンビン; 血液凝固反応; 凝固XIII因子; 血小板; 線溶; Glaドメイン; 血漿タンパク質; ワーファリン; リボソームタンパク質; 単球; 白血球走化因子; C5aレセプター; 凝血塊吸収; S19リボソームタンパク質; 単球走化因子; 血液凝固XIII因子; 細胞性線溶; 血栓症

In the present research, we have revealed that ribosomal protein S19(RP S19) present in normal blood plasma is covalently dimerized by activated factor XIII on the activated platelet surface and gains monocyte chemotactic capacity during blood coagulation process, that the RP S19 dimer recruits monocytes to the coagulum resulting in cellular fibrinolytic absorption of the coagulum, and that monocytotic state of peripheral blood enhance the coagulum resorption process.

In the present research, we have revealed that ribosomal protein S19(RP S19) present in normal blood plasma is covalently dimerized by activated factor XIII on the activated platelet surface and gains monocyte chemotactic capacity during blood coagulation process, that the RP S19 dimer recruits monocytes to the coagulum resulting in cellular fibrinolytic absorption of the coagulum,外周血的单核细胞状态增强了凝结吸收过程。