Effects of endocrine disrupters on function of thyroid gland, adrenal glands and gonads

内分泌干​​扰物对甲状腺、肾上腺和性腺功能的影响

• 批准号: 11839003
• 负责人: TAYA Kazuyoshi
• 金额: $ 2.3万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11839003/
• 关键词: Endocrine disrupter; Bisphenol A; Octylphenol; Genistein; testosterone; inhibin; Prolactin; rats; シャトルボックス回避能; HAA、LAAラット; Hatanoラット; 内分泌撹乱作用; 春機発動; 自発運動量; 免疫機能; 精子形成

The present study investigated the effects of a xenobiotic estrogen, Bisphenol A(BPA)and Octylphenol(OP)on reproductive functions using male and female rats. Results indicated that BPA and OP directly inhibit testicular functions. The testis is probably a more sensitive site for BPA and OP actions than the hypothalamus-pituitary axis. On the other hand, the exposure of neonatal female rats to higher doses of OP disrupts the cyclic release of LH, FSH and prolactin, and interferes with the display of sexual receptive behavior in adulthood.The Hatano high- and low-avoidance animals(HAAs and LAAs), selectively bred from Sprague-Dawley rats, are characterized as an intra-strain dissociation in avoidance learning, locomotor activity, puberty, estrous cycles, sperm motility, hypothalamo-pituitary-adrenal(HPA)axis and immune response. The present study was therefore designed to compare the effects of lactational exposure to genistein, a phytoestrogen, on those functions between HAAs and LAAs. … More To this aim, litters from both strains were fostered onto Sprague-Dawley rats, which were administered from gestational day 17 to postnatal day 21. In LAAs, puberty was significantly delayed in the both sexes of offspring reared by genistein-treated dams compared with those by vehicle-treated dams, whereas no significant effects of genistein on puberty were observed in HAAs. Open field activity was significantly increased in male HAAs that reared by genistein-treated dams. The number of lymphocytes and antibody production response to sheep red blood cells were significantly decreased in HAAs reared by genistein-treated dams. No genistein-related but strain-related differences were detected in estrous cycling, learning behavior, sperm motility and weight of reproductive organs. These results demonstrated that genistein has endocrine disrupting effects on behavior, reproduction and immune response of rats when exposures during lactation. These results also indicated that there are clear differences of endocrine disrupting effects in two genetically selected strain rats. Less

本研究研究了使用雄性和雌性大鼠的雌激素雌激素，双酚A（BPA）和辛基酚（OP）对生殖功能的影响。结果表明BPA和OP直接抑制了检测功能。与下丘脑 - 垂体轴相比，睾丸可能是BPA和OP动作更敏感的部位。 On the other hand, the exposure of neonatal female rats to higher doses of OP disrupts the cyclic release of LH, FSH and prolactin, and interfere with the display of sexual receptive behavior in adulthood.The Hatano high- and low-avoidance animals(HAAs and LAAs), selectively bred from Sprague-Dawley rats, are characterised as an intra-strain dissociation in avoidance learning, locomotor activity,青春期，发情循环，精子运动，下丘脑 - 垂体 - 肾上腺（HPA）轴和免疫反应。因此，本研究的设计旨在比较乳木黄酮（一种植物雌激素）对HAAS和LAAS之间的功能的影响。 …为此目的而言，两种菌株的垃圾都被养成了Sprague-Dawley大鼠，从遗传学第17天到产后第21天进行了服用。在Laas，在Laas中，由Genastein Parsed Dams养成的后代的两个性别都大大延迟了，与车辆培训的大坝相比，该水坝与经过培养的大坝相比，对Generease whe egeneasein conty puneisein be nawe n of the Genty puneistein consisine veneasein be n n n n n n n n n n n n n n n n n n n n no the n no the。通过染料木黄酮治疗的大坝饲养的雄性HAA，开放式活动显着增加。通过染料木黄酮治疗的大坝饲养的HAA，淋巴细胞的数量和对绵羊红细胞的抗体产生反应显着减少。在发情循环，学习行为，精子运动和生殖器官的重量中，未检测到与染料木黄酮有关的差异。这些结果表明，当泌乳期间暴露时，染料木黄酮对大鼠的行为，繁殖和免疫反应的影响有内分泌的影响。这些结果还表明，在两名遗传选择的菌株大鼠中，内分泌破坏作用存在明显差异。较少的

项目成果

Heratl, C. B.: "Exposure of neonatal female rats to p-tert-octylphenol disrupts afternoon surges of LH, FSH and prolactin secretion, and interferes with sexual receptive"Biology of Reproduction. 64. 1216-1224 (2001)

Heratl, C. B.：“新生雌性大鼠接触对叔辛基苯酚会扰乱午后 LH、FSH 和催乳素分泌的激增，并干扰性接受”《生殖生物学》。

Tohei, A.: "Hypothyroidism increases prolactin secretion and decreases the intromission threshold for induction of pseudopregnancy in adult female rats"Physicology and Beharion. 69. 391-397 (2000)

Tohei, A.：“甲状腺功能减退症会增加催乳素的分泌，并降低成年雌性大鼠假孕诱导的插入阈值”《生理学》和《Beharion》。

Katsuda,S.,Yoshida,M.,Watanabe,G.Taya,K.and Maekawa,A.: "Irreversible effects of neonatal exposure to P-test-octylPkansl on the reproductive tract in female rats."Taxicology and Applied Pharmacology. 165. 217-226 (2000)

Katsuda,S.、Yoshida,M.、Watanabe,G.Taya,K. 和 Maekawa,A.：“新生儿接触 P-test-octylPkansl 对雌性大鼠生殖道的不可逆影响。”毒理学和应用药理学。

Tohei A., Suda S., Taya K., Hashimoto T.and Kogo H.: "Bisphenol A inhibits testicular function and increases LH secretion in adult male rats."The Proceedings of the Society for Experimental Biology and Medicine. 226. 216-221 (2001)

Tohei A.、Suda S.、Taya K.、Hashimoto T. 和 Kogo H.：“双酚 A 抑制成年雄性大鼠的睾丸功能并增加 LH 分泌。”实验生物学与医学学会会刊。

Tohei, A.: "Bisphenol A inhibits teotiarlar function and inneases LH seaetion in adult male rats"The Pruceedirgs of the Soaety for Experinental Biology and Medicino. 226. 216-221 (2001)

Tohei, A.：“双酚 A 抑制成年雄性大鼠的足部功能并促进 LH 分泌”实验生物学和医学协会的规程。