Roles of Thyroid and adrenal glands in the regulation of gonadotropins secretion during lactation in the rat

甲状腺和肾上腺在大鼠哺乳期促性腺激素分泌调节中的作用

基本信息

批准号：
03660306
负责人：
TAYA Kazuyoshi
金额：
$ 1.41万
依托单位：
Tokyo University of Agriculture and Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

项目摘要

The roles of thyroid and adrenal glands in the regulation of LH and FSH secretion were investigated during lactation in rats. Changes in plasma concentrations of T3 and T4 were measured by RIAs throughout pregnancy and lactation. Plasma concentrations of T3 and T4 gradually decreased in the period of pregnancy and the low levels of both hormones were maintained throughout lactation. Ovariectomy on day 2 of lactation (day of parturition = day 0 of lactation) resulted in no difference in levels of T3 and T4 in the plasma as compared with those of sham-operated animals. Plasma levels of T3 and T4 increased after removal of the litter. These results clearly indicated that lactation is accompanied by hypothyroid state in the rat.In the lactating rat, an increase in plasma levels of corticosterone in response to immobilization stress was suppressed as compared with those of non-lactating rats. Removal of the litter restored the reduced response to immobilization stress. The reduced response of secretion of corticosterone to immobilization stress was accompanied by the hypothyroid state during lactation in the rat. Experimentally induced hypothyroid state in non-lactating female rats also suppressed the response of corticosterone secretion to immobilization stress and the replacement of T4 in the hypothyroid rat restored the response to the stress.These findings suggest that thyroid function well correlated with the function of adrenal cortex and hypothyroidal and hypoadrenal state resulted in hypogonadal state in the lactating rat.

在大鼠泌乳期间研究了甲状腺和肾上腺在LH和FSH分泌的调节中的作用。 T3和T4血浆浓度的变化是通过RIAS在整个妊娠和哺乳期中测量的。 T3和T4的血浆浓度在怀孕期间逐渐降低，并且两种激素的水平都保持在整个哺乳期。与假手术动物相比，泌乳的第2天（分娩日=泌乳日=第0天）的卵巢切除术在等离子体中的T3和T4水平没有差异。去除垃圾后，T3和T4的血浆水平升高。这些结果清楚地表明，泌乳伴有大鼠中的甲状腺功能减退状态。在泌乳大鼠中，与非泌乳大鼠相比，抑制了固定胁迫的血浆皮质酮水平升高被抑制。去除垫料可恢复对固定应力的减少反应。皮质酮对固定胁迫的分泌反应减少，伴随着大鼠泌乳期间的甲状腺功能减退态。实验诱导的非乳酸雌性大鼠中的甲状腺功能减退症也抑制了皮质酮分泌对固定压力的反应和甲状腺功能减退大鼠中T4的替代的反应，恢复了对胁迫的反应。这些发现表明，这些发现与肾上腺皮质的功能良好相关，并催生了下属的脑部和下型。