Roles of Thyroid and Adrenal glands in the regulation of hypothalamo-hypophysial-ovarian axis in the rat.

甲状腺和肾上腺在大鼠下丘脑-垂体-卵巢轴调节中的作用。

基本信息

批准号：
06660375
负责人：
TAYA Kazuyoshi
金额：
$ 1.34万
依托单位：
Tokyo University of Agriculture and Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06660375/
关键词：
Rat stress Thyroid gland Adrenal gland Ovary Prolactin ACTH Gonadotropin 性腺甲状腺刺激ホルモン放出ホルモン(TRH)

项目摘要

The functional relationship between thyroid, adrenal and gonadal hormones was investigated using adult male rats. Hypothyroidism was produced by the administration of 4-methy1-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Plasma concentrations of TSH dramatically increased, whereas plasma concentrations of tri-iodothyronine and thyroxine decreased in thiouracil-treated rats as compared with euthyroid rats.Hypothyroidism increased basal levels of plasma ACTH and pituitary content of ACTH.The pituitary responsiveness to CRH for ACTH release markedly increased, whereas the adrenal responsiveness to ACTH for corticosterone release decreased. These results indicated that hypothyroidism causes adrenal dysfunction in adult male rats. Pituitary contents of LH and prolactin decreased in hypothyroid rats as compared with euthyroid rats. In addition, hypothyroidism lowered pituitary LH responsiveness to LHRH.Testicular responsiveness to human chorionic gonadotrophin for testosterone release, however, was not different between euthyroid and hypothyroid animals. These results indicated that hypothyroidism causes adrenal dysfunction and results in hypersecretion of ACTH from the pituitary gland. Adrenal dysfunction may contribute to the inhibition of LHRH secretion from the hypothalamus, possibly mediated by excess CRH.

使用成年雄性大鼠研究了甲状腺，肾上腺和性腺激素之间的功能关系。甲状腺功能减退症是通过在饮用水中的4-甲基1-2-硫核（Thiouracil）给药2周产生的。 Plasma concentrations of TSH dramatically increased, whereas plasma concentrations of tri-iodothyronine and thyroxine decreased in thiouracil-treated rats as compared with euthyroid rats.Hypothyroidism increased basal levels of plasma ACTH and pituitary content of ACTH.The pituitary responsiveness to CRH for ACTH release markedly increased, whereas the adrenal responsiveness to ACTH for皮质酮释放减少。这些结果表明，甲状腺功能减退会引起成年雄性大鼠的肾上腺功能障碍。与甲状腺功能亢进的大鼠相比，甲状腺功能减少大鼠的LH和催乳素的垂体含量降低。此外，甲状腺功能减退症降低了对LHRH的垂体LH反应性。然而，对睾丸激素释放的人类绒毛膜促性腺激素的细胞反应能力在甲状腺功能蛋白酶和甲状腺功能下动物之间并没有差异。这些结果表明，甲状腺功能减退会引起肾上腺功能障碍，并导致垂体中ACTH的分泌过度。肾上腺功能障碍可能导致下丘脑的LHRH分泌抑制，这可能是由过量的CRH介导的。