Studies on neuroendocrinological mechanisms of memory in the Hatano rats

波多野大鼠记忆的神经内分泌机制研究

基本信息

批准号：
13660296
负责人：
TAYA Kazuyoshi
金额：
$ 1.86万
依托单位：
Tokyo University of Agriculture and Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13660296/
关键词：
Hatano rats avoidance learning inhibin stress response ACTH prolactin corticosterone FSH 精子運動性性成熟異常精子率

项目摘要

Hatano high avoidance (HAA) and low avoidance (LAA) strains rats have been originally selected and bred from Sprague-Dawley rats for their shuttle-box task. The present study focused on the activity of the hypothalamo-pituitary-adrenocortical axis (HPA) of HAA and LAA rats in response to restraint stress. The restraint stress induced an elevation of plasma concentrations of ACTH, prolactin, corticosterone and progesterone, and in adrenal concentrations of coricosterone and progesterone. Peak levels of plasma ACTH during stress condition were significantly higher in HAA rats than LAA rats, while peak levels of prolactin were significantly lower in HAA rats than LAA rats. ACTH and prolactin syntheses in anterior pituitary glands were significantly higher in HAA rat than LAA rats during stress. The plasma concectrations of corticosterone, as shown bv percentage of initial values, during stress were significantly higher in HAA rats than LAA rats. Adrenal concentrations of corticosterone and progesterone increased during stress in both strains, although no significant strain deference was observed between HAA and LAA. These results indicate that the activities of HPA axis to acute restraint stress are higher in HAA rats than LAA rats, whereas prolactin secretory activity is vice versa. These endocrine differences in response to stress may be involved in regulation of memory.

Hatano High Reveedance（HAA）和低回避（LAA）菌株最初是从Sprague-Dawley大鼠中选择并饲养的，用于穿梭盒子的任务。本研究的重点是HAA和LAA大鼠的下丘脑 - 垂体 - 肾上腺皮质轴（HPA）的活性，以响应约束应激。约束应力引起血浆浓度的ACTH，催乳素，皮质酮和孕酮的升高，以及肾上腺浓度的冠型和孕酮。 HAA大鼠在应力条件下血浆ACTH的峰值水平明显高于LAA大鼠，而HAA大鼠的催乳素水平明显低于LAA大鼠。在压力下，HAA大鼠的前垂体中的ACTH和催乳素合成在HAA大鼠中明显高于LAA大鼠。在HAA大鼠的压力中，皮质酮的血浆肠道牙齿的血浆概念比LAA大鼠高得多。两种菌株中肾上腺皮质酮和孕酮的肾上腺浓度增加，尽管HAA和LAA之间未观察到明显的应变尊重。这些结果表明，HAA大鼠中HPA轴对急性约束应力的活性高于LAA大鼠，而催乳素分泌活性反之亦然。这些响应压力的内分泌差异可能与记忆的调节有关。