Performance of magnetic resonance elastography measuring the minimal displacements of the tissue generated by external oscillation and its clinical application.

磁共振弹性成像测量外部振荡产生的组织最小位移的性能及其临床应用。

• 批准号: 11670898
• 负责人: HONDA Hiroshi
• 金额: $ 2.3万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670898/
• 关键词: MR; elasticity; strain imaging; MR elastography

The purpose of this study was to estimate tissue elasticity using magnetic resonance elastography (MRE) and to try its clinical application. We prepared a tissue-like phantom with two different stiffness. External oscillation generated minimum displacements of the phantom and phase contrast image captured different shear waves propagation and shear modulus of phantom were well correlated with stiffness of phantom. Ex vivo pig liver and pathology generated by laser ablation were used for animal study. Shear wave propagation through animal liver were shown and ablated tissue was stiffer than non-ablated tissue on MRE. Shear modulus of ex vivo human cirrhotic liver was different from non-cirrhotic liver. Cirrhotic liver was stiffer than non-cirrhotic liver because cirrhotic liver had fibrosis. We also measured elasticity of resected human liver tumor. Cholangiocellular carcinoma with massive fibrosis was stiffer than surrounding liver and hepatocellular carcinoma was softer than surrounding liver using palpation and external compression apparatus. Elastic modull of tumors estimated by MRE technique were correlated with palpation and measured elastic value. MRE had a potential to noninvasively estimate human's elastic properties and to be a new diagnostic tool.

这项研究的目的是使用磁共振弹性图（MRE）估算组织弹性，并尝试其临床应用。我们准备了一个具有两个不同刚度的组织样幻影。外部振荡产生了幻影的最小位移，相比图像捕获了不同的剪切波的传播和幻影的剪切模量与幻影的刚度很好地相关。用激光消融产生的体内猪肝和动物研究。显示了通过动物肝脏传播的剪切波传播，并且在MRE上的非灭火组织冻结了烧蚀的组织。离体人肝硬化肝的剪切模量与非卷肝肝脏不同。肝硬化肝脏比非肝脏肝脏更硬，因为肝硬化肝脏具有纤维化。我们还测量了切除的人肝肿瘤的弹性。与周围的肝脏相比，具有大量纤维化的胆管细胞癌更加严峻，肝细胞癌比使用触诊和外部压缩设备柔和周围的肝脏。通过MRE技术估计的肿瘤弹性与触诊和测量的弹性值相关。 MRE具有非侵入性估计人类弹性特性的潜力，并成为一种新的诊断工具。

项目成果

Ishibashi H, et al.: "Hypoxia-Induced Angiogenesis of Cultured Human Salivary Gland Carcinoma CellsInvolves Enhancement VEGF Production and bFGF Release"Oral Oncology. 37. 77-83 (2001)

Ishibashi H 等人：“培养人唾液腺癌细胞的缺氧诱导血管生成涉及增强 VEGF 产生和 bFGF 释放”口腔肿瘤学。

本田 浩: "MR elastography"Radiology Frontier. 5・3(in press). (2002)

本田浩：“MR 弹性成像”放射学前沿 5・3（印刷中）。

Nakagawa K, Chen Y, Ishibashi H, et al.: "Angiogenesis and its regulation : roles of vascular endothelial cell growth factor (VEGF)"Semin Thromb Hemost. 143. 201-206 (2000)

Nakakawa K、Chen Y、Ishibashi H 等人：“血管生成及其调节：血管内皮细胞生长因子 (VEGF) 的作用”Semin Thromb Hemost。

M Onimaru et al.: "FGF-2 stimulates HGF expression, regardless to hypoxia-mediated down regulation in ischemic limb"Circulation Res. (In press).

M Onimaru 等人：“无论缺血肢体中缺氧介导的下调如何，FGF-2 都会刺激 HGF 表达”循环研究。

本田 浩: "MR elastography"Radiology Frontier. 5(3)(in press). (2002)

本田浩：“MR 弹性成像”放射学前沿 5(3)（印刷中）。