Normal & Shear Strain Imaging From Angled US Acquisition

普通的

• 批准号: 6936622
• 负责人: TOMY VARGHESE
• 金额: $ 17.81万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-16 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936622
• 关键词: bioimaging /biomedical imaging; breast neoplasm /cancer diagnosis; diagnosis design /evaluation; elasticity; image enhancement; image processing; mathematical model; method development; radiowave radiation; shear stress; thyroid neoplasm; ultrasonography

DESCRIPTION (provided by applicant): The current practice of elastography, images only the axial component of the strain tensor, while the lateral and elevational strain tensor components are basically disregarded. In the absence of lateral and elevational components, other important elastic parameters such as shear strains and Poisson's are not imaged. Moreover, efforts at reconstruction of the Young's modulus from strain data would be significantly improved if all the normal and shear strain tensors are available. In this research, we propose a novel method of estimating displacements and strains in axial, lateral and elevational directions in ultrasound elastography imaging. The method uses tissue displacement components estimated along multiple angular ultrasound beam directions acquired with linear array transducers. Strain elastograms of normal and shear tensors are then calculated from the axial and lateral displacement information in addition to Poisson's ratio information. The research plan develops and optimizes this method for a state-of-the-art scanner using simulations to evaluate tradeoffs between acquisition rate, angles and data accuracy. Implementation of the techniques will be on the Siemens Antares scanner, capitalizing on a newly developed ultrasound research interface to facilitate angular beam data acquisition and control. Tests using elastography phantoms will yield performance benchmarks. Two new phantom types will also be developed to evaluate the ability to derive the fundamental information expected in these images. Finally, excised tissue samples will be imaged to evaluate the new elasticity information obtained. Clinical applications where the methodology will be directed are in differentiating malignant from benign masses in the breast and thyroid. In both sites lateral slippage is believed to occur in many benign masses when the tissue is compressed, while slippage appears to be absent with malignant masses. The proposed lateral and shear strain images are expected to be particularly sensitive to such phenomena.

描述（由申请人提供）： 当前的弹性学实践，仅图像应变张量的轴向成分，而横向应变张量成分基本上被忽略了。在没有侧向和高程组件的情况下，未成像其他重要的弹性参数，例如剪切菌株和泊松。此外，如果所有正常和剪切应变张量可用，则从应变数据中重建年轻模量的努力将显着改善。在这项研究中，我们提出了一种新型的方法，用于估计超声弹力摄影成像中轴向，横向和高度方向的位移和菌株。该方法使用沿线性阵列传感器获得的多个角度超声梁方向估计的组织位移成分。然后，除了Poisson的比率信息之外，还根据轴向和侧向位移信息计算出正常和剪切张量的应变弹性图。 该研究计划使用模拟来评估获取率，角度和数据准确性之间的权衡方案，为最先进的扫描仪开发并优化了此方法。这些技术的实施将在西门子的安塔雷斯扫描仪上，利用新开发的超声研究界面，以促进角梁数据获取和控制。使用弹性幻像的测试将产生性能基准。还将开发两种新的幻影类型，以评估这些图像中预期的基本信息的能力。最后，将成像切除的组织样品，以评估获得的新弹性信息。 该方法将被指示的临床应用与乳房和甲状腺中的良性肿块区分开。在两个部位中，当组织被压缩时，在许多良性肿块中都会出现侧向滑动，而恶性肿瘤似乎不存在滑移。所提出的侧面和剪切应变图像有望对这种现象特别敏感。