MECHANICAL TISSUE CHARACTERIZATION AND STRESS / STRAIN IMAGING OF MURINE HEART

小鼠心脏的机械组织特征和应力/应变成像

• 批准号: 8363222
• 负责人: PANOS P CONSTANTINIDES
• 金额: $ 0.31万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363222
• 关键词: Anatomy; Atomic Force Microscopy; Behavior; Cardiac; Characteristics; Computational Technique; Elasticity; Elastomers; Funding; Grant; Heart; Human; Hydrogels; Image; Laws; Magnetic Resonance Imaging; Mechanics; Methodology; Microscopy; Modeling; Morphology; Mus; National Center for Research Resources; Organ; Principal Investigator; Property; Research; Research Infrastructure; Resources; Source; Stress; Tensile Strength; Tissue Engineering; Tissues; United States National Institutes of Health; base; chemical synthesis; cost; density; in vivo; manufacturing process; mouse model; multimodality; programs; shear stress; two-dimensional

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The specific scientific and technological objectives of this program are: A. Image based modeling and rapid prototyping manufacturing processes can produce two-dimensional (2D) and three-dimensional (3D) tissue mimicking models of the mouse and human cardiac anatomy. B. Standard chemical synthesis methodologies can produce engineered tissue mimicking materials (elastomers, hydrogels) that match the morphology and emulate the in vivo murine and human cardiac tissue mechanical and imaging characteristics. C. Mechanical properties of tissue engineered and murine cardiac myofibers can be accurately and precisely characterized ex-vivo. Specifically: C.1 There are non-significant differences between strain, stress, shear modulus of elasticity, Poisson ratio, density estimates, maximum force and tensile strength developed, of the synthesized tissue mimicking materials and the murine heart C.2 There are significant differences between local (tissue) and global (organ) estimates of tissue elasticity of the fixed murine heart, determined by atomic force microscopy D. Constitutive law behavior of engineered tissue mimicking materials and the in vivo heart, can be accurately and precisely computed with model-based 3D- and 4D-computational techniques using MRI, and validated under dynamic conditions using a multimodality cardiac phantom and in vivo.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该计划的具体科学和技术目标是： A.基于图像的建模和快速原型制造工艺可以产生二维（2D）和三维（3D）组织模仿小鼠和人类心脏解剖学的模型。 B.标准化学合成方法可以产生模仿形态与形态并模仿体内鼠和人类心脏组织机械和成像特征的工程组织（弹性体，水凝胶）。 C.组织工程和鼠心脏肌纤维的机械性能可以准确而精确地表征前体。具体来说： C.1应变，应力，弹性剪切模量，泊松比，密度估计，最大力和拉伸强度，合成的组织模仿材料和鼠心的差异差异很大。 C.2固定鼠心脏的组织弹性局部（组织）和全局（器官）估计值之间存在显着差异，该组织由原子力显微镜确定 D.工程组织模仿材料和体内心脏的构成法律行为，可以使用MRI准确，精确地使用基于模型的3D和4D计算技术来计算，并使用多型心脏幻像和体内的动态条件进行验证。