New chemo-thermotherapy for malignant brain tumor using 40ﾟCC thermosensitive liposome

40ﾟCC热敏脂质体治疗恶性脑肿瘤的新型化疗热疗法

基本信息

批准号：
08557081
负责人：
TANAKA Ryuichi
金额：
$ 5.31万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08557081/
关键词：
marignant brain tumor glioma chemotherapy hyperthermia thermosensitive liposome blood brain barrier drug delivery system ADR

项目摘要

Thermosensitive liposomes are microscopic vesicles that are designed to release their contained drugs effectively in response to hyperthermia. Previously we revealed the combination of thermosensitive liposome containing CDDP and local barin heating showed remarkable antitumor effects against rat malignant gliomas (Int J Hyperthermia : 157-165,1996. J Neurosurg : 180-184, 1996). A new thermosensitive liposome was prepared considering this drug delivery system as clinical use. While a transition temperature of the conventional liposomes have been 42 or 43ﾟCC to enhance the synergistic effect of hyperthermia and antitumor drugs, the area above 42ﾟCC was localized in a narrow portion of human glioma around the RF antenna. But the area of 40ﾟCC extended up to the wide portion of it. So we prepared thermosensitive liposome which can release adriamycin (ADR) above 40ﾟCC.This liposome showed a significantly great antitumor effect against rat gliomas at 40ﾟCC.This procedure 1) contributes to the synergistic effect of hyperthermia and antitumor drugs in the regions above 42ﾟCC, 2) helps to deliver the antitumor drugs more widely to glioma with the temperature of 40ﾟCC, 3) gives a good chance to many antitumor drugs, such as ADR, which have not been used because they were blocked by BBB despite of their greater antitumor effects.

热敏脂质体是一种微观囊泡，旨在响应热疗而有效释放其所含药物。之前我们发现，含有CDDP的热敏脂质体与局部巴林加热的组合对大鼠恶性胶质瘤显示出显着的抗肿瘤作用（Int J Hyperthermia：157-165， 1996. J Neurosurg : 180-184, 1996)。考虑到该药物递送系统的临床应用，制备了脂质体。虽然传统脂质体的转变温度为42或43℃以增强热疗和抗肿瘤药物的协同作用，但42℃以上的区域仅限于狭窄的部分。射频天线周围的人类胶质瘤的面积达到了40ﾟCC，因此我们制备了可以释放的热敏脂质体。阿霉素（ADR）在40ﾟCC以上。该脂质体在40ﾟCC以上的区域对大鼠神经胶质瘤显示出显着的抗肿瘤作用。该程序1）有助于在42ﾟCC以上区域热疗和抗肿瘤药物的协同作用，2）有助于将抗肿瘤药物更广泛地输送到温度为 40°C 的神经胶质瘤，3）给了许多人一个很好的机会抗肿瘤药物，如ADR，尽管其抗肿瘤作用较大，但由于被BBB阻断而未得到使用。