A new chemothermotherapy focusing to the tumor invading zone of malignant glioma by thermosensitive liposome

热敏脂质体针对恶性胶质瘤肿瘤侵袭区的新型化疗

基本信息

批准号：
09557115
负责人：
TANAKA Ryuichi
金额：
$ 4.67万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09557115/
关键词：
thermosensitive liposome malignant glioma chemotherapy hyperthermia tumor invading zone adriamycin

项目摘要

The area surrounding the core of malignant glioma was already infiltrated by tumor cells ( tumor invading zone ) and was commonly unresectable resulting in its regrowth and poor prognosis. However, up to date, there have been few attempts to focus the treatment of this tumor invading zone. We developed a new targeting chemo-thermotherapy focusing to the tumor core, and also to the tumor invading zone. Thermosensitive liposomes are microscopic vesicles that can contain drugs and release them effectively in response to hyperthermia. Our hyperthermic treatment, above 42 - 43 ℃, can treat the entire tumor core of human malignant glioma for direct thermal killing. When heating, the 40 ℃ area extended up to a wide portion, covering the tumor invading zone. Therefore, new thermosensitive liposomes containing Adriamycin ( ADR ) were prepared to release their content at 40 ℃ and above. Consequently, this new thermosensitive liposome sharply released ADR as planned, and high concentrations of ADR was focused in both rat brain tumor ( >42 ℃ ) and the surrounding brain tissue which corresponds to the tumor invading zone ( at 42 - 40 ℃ ). These results suggest that this new procedure 1) helps to deliver the antitumor drugs selectively and wider : to the tumor core, and also to the tumor invading zone, 2) shows no thermal damages of normal brain tissue in the tumor invading zone with lower temperatures, 3) permits ADR and other antitumor drugs to be used regardless the BBB problem, 4) contributes to the synergistic effect of antitumor drugs and hyperthermia. This new liposomal therapy can be used clinically as a superior targeting chemo-thermotherapy of malignant gliomas.

恶性神经胶质瘤核心周围的区域已经被肿瘤细胞（肿瘤入侵区）渗透，通常无法切除，导致其改革和预后不良。但是，最新的是，很少有尝试集中于该肿瘤入侵区的治疗。我们开发了一种针对肿瘤核心以及肿瘤入侵区域的新靶向化学疗法。热敏脂质体是微观蔬菜，可以含有药物并有效地释放出对高温的有效释放。我们的高温治疗高于42-43°C，可以治疗人类恶性神经胶质瘤的整个肿瘤核心，以直接杀死热杀死。加热时，40°C的区域延伸到宽部分，覆盖了肿瘤入侵区。因此，准备在40°C及以上释放含有阿霉素（ADR）的新型热敏脂质体（ADR）。因此，这种新的热敏脂质体按计划迅速释放出ADR，高浓度的ADR集中在大鼠脑肿瘤（> 42℃）和周围的脑组织中，该脑组织与肿瘤入侵区（42-40℃）相对应。这些结果表明，这项新程序1）有助于选择性地输送抗肿瘤药物并更宽：肿瘤核心，也可以到达肿瘤入侵区，2）显示，在较低的温度下，在肿瘤入侵区中正常脑组织的热损害没有损害，3）允许使用ADR和其他抗肿瘤药物对BBB造成的药物，4）作用，4）贡献Insgistic condistic cons cons to and N.）贡献Ins的贡献。热疗。这种新的脂质体疗法可在临床上用作恶性神经胶质瘤的化学热疗法的优质化学疗法。