How does an essential histone variant effect changes in gene expression?

重要的组蛋白变异如何影响基因表达的变化？

• 批准号: DP220101716
• 负责人: Prof Joel Mackay
• 金额: $ 31.33万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-02-18 至 2025-02-17
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101716
• 关键词: How; does; essential; histone; variant

The mechanisms that determine how genes are switched on and off in different tissues and at different times are not clearly known. It is well established that gene expression patterns are determined in part by the molecular signals transmitted by variation in the proteins that package eukaryotic DNA. Our aim is to understand new aspects of these mechanisms that revolve around how our DNA is packaged. This foundational knowledge will deepen our understanding of gene regulation in all complex organisms and will inform future efforts to rationally modulate gene expression patterns in agriculture, research and other important areas.

确定基因在不同组织和不同时间打开和关闭基因的机制尚不清楚。众所周知，基因表达模式部分由包装真核DNA的蛋白质变异传递的分子信号确定。我们的目的是了解这些机制的新方面，这些机制围绕着我们的DNA包装方式。这种基本知识将加深我们对所有复杂生物体基因调节的理解，并将为未来的努力提供理性调节农业，研究和其他重要领域的基因表达模式的努力。