How does the chromatin remodeller CHD4 regulate gene expression?

染色质重塑因子 CHD4 如何调节基因表达？

• 批准号: DP240102119
• 负责人: Prof Joel Mackay
• 金额: $ 53.6万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102119
• 关键词: How; does; chromatin; remodeller; CHD4; How; does; chromatin; remodeller; CHD4

The mechanisms that determine how genes are switched on and off in different tissues and at different times are in many ways still mysterious. It is well established that gene expression patterns in complex organisms are determined in part by the manner in which DNA is physically packaged. Our aim is to define new aspects of these mechanisms that revolve around molecular motors that regulate DNA packaging. This foundational knowledge will deepen our understanding of gene regulation in all complex organisms and will inform future efforts to rationally modulate gene expression patterns in agriculture, research and other important areas.

决定基因在不同组织中和不同时间的打开和关闭方式的机制在许多方面仍然是神秘的。众所周知，复杂生物体中的基因表达模式部分取决于DNA物理包装的方式。我们的目的是定义这些机制的新方面，这些机制围绕调节DNA包装的分子电机。这种基本知识将加深我们对所有复杂生物体基因调节的理解，并将为未来的努力提供理性调节农业，研究和其他重要领域的基因表达模式的努力。