Plasticity and accommodation in the brain mechanism of transmission

大脑传输机制中的可塑性和适应性

• 批准号: 07304055
• 负责人: ICHIKAWA Masumi
• 金额: $ 6.59万
• 依托单位: Tokyo Metropolitan Institute for Neuroscience
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07304055/
• 关键词: Neuron; Terminal nerve; GnRH; Pulse generator; Hormone; Synapse; Neuropeptide; Neuromodulator; 神経系; 神経伝達物質

Molecular characteristics of GnRH receptor were analized and expression of mRNA of GnRH studied in situ hybridization.Development of GnRH neurons was studied. Straying phenomenon of migrating GnRH neurons was found and the presebce of highly polysialated NCAN in the migrating route was identified in chick embryo.Plasticity of GnRH neurons was studied. The neurons were induced structural changes by pheromonal stimulations.Characterization of TTX-resistant persistent Na+ current underlying pacemaker potentials wes found in fish gonadotropin-releasing hormone (GnRH) neuronsHypophyseal portal blood collection for analysis of GnRH neurosecretion was succeeded in Shiba goatsTumor necrosis factor induced suppression of GnRH pulse generator activity in the rat.Suppression of GnRH pulses by restriction of glucose avalability is mediated by sensors in the brain stem was elucidated.Distribution of GnRH neurons was studied immunocytochemicall in doldfish brain. It was demonstrated a marked decrease of GnRH neurons after transection of olfactory tract.

分析了GnRH受体的分子特征，原位杂交研究了GnRH mRNA的表达。研究了GnRH神经元的发育。发现了鸡胚GnRH神经元迁移过程中的迷失现象，并鉴定了鸡胚迁移过程中是否存在高度多唾液酸化的NCAN。对GnRH神经元的可塑性进行了研究。信息素刺激诱导神经元发生结构变化。在鱼类促性腺激素释放激素 (GnRH) 神经元中发现了抗 TTX 持续 Na+ 电流潜在起搏器电位的特征在柴山羊中成功采集垂体门静脉血液以分析 GnRH 神经分泌肿瘤坏死因子诱导的抑制大鼠中 GnRH 脉冲发生器活性的影响。通过限制葡萄糖可用性来抑制 GnRH 脉冲是由阐明了脑干中的传感器。免疫细胞化学研究了白斑鱼大脑中GnRH神经元的分布。结果表明，嗅道横断后 GnRH 神经元显着减少。

项目成果

Kim MH, Oka Y, Amano M, Kobayashi M, Okuzawa K, Hasegawa Y, Kawashima S, Suzuki Y, Aida K.: "Immunocytochemical localozation of sGnRH and cGnRH-II in the brain of goldfish, Carassius auratus." J. Comp. Neurol.,. 356. 72-82 (1995)

Kim MH, Oka Y, Amano M, Kobayashi M, Okuzawa K, Hasekawa Y, Kawashima S, Suzuki Y, Aida K.：“金鱼鲫鱼大脑中 sGnRH 和 cGnRH-II 的免疫细胞化学定位。”

Yoo MJ,Nishihara M,and Takahashi M: "Tumor necrosis factor-a mediates endotoxin induced suppression of gonadotropin-releasing hormone pulse generator activity in the rat." Endocrine J. 44. 141-148 (1997)

Yoo MJ、Nishihara M 和 Takahashi M：“肿瘤坏死因子-a 介导内毒素诱导的大鼠促性腺激素释放激素脉冲发生器活性的抑制。”

Akazome Y,Par, MK,and Mori T: "Highly heterologous region in the N-terminal extracellular of reptilian follitropin receptors." Gen. Comp. Endocrinol.104. 374-381 (1996)

Akazome Y、Par、MK 和 Mori T：“爬行动物促卵泡素受体 N 末端细胞外的高度异源区域。”