Morphological analysis of plastic changes induced by environment on synapses in rat olfactory system

环境引起的大鼠嗅觉系统突触塑性变化的形态学分析

• 批准号: 06640871
• 负责人: ICHIKAWA Masumi
• 金额: $ 1.22万
• 依托单位: Tokyo Metropolitan Institute for Neuroscience
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06640871/
• 关键词: Oifaction; Vomeronasal system; Pheromon; Synapse; Plasticity; ハムスター; 鋤鼻神経

It has been known that the soiled bedding and the urin contain pheromonal substances.Thus, in orderto study pheromonally induced synaptic plasticity in the vomeronasal system, effects of soiled bedding and urin has been examined in the accessory olfactory bulb (AOB).(1) The effects of exposure to soiled bedding on synaptic morphology in the AOB were examined in adult male rats.One group was exposed to bedding soiled by male and female rats (male and female group).Another group was exposed to bedding soiled by only males (male group).A third group was exposed to clean bedding (clean group).After 2 months, the mean size of the synapses was significantly greater in the male and female group than in the clean group, whereas that in the male group appeared to be intermediate between those in the male and female and the clean groups, but was not significantly different.These results suggest that exposure to a more complex soiled bedding environment can induce greater structural changes of the synapses in the AOB of male adult rats.(2) The effect of urinary pheromones on the synapses of male AOBs has been studied.Urine is collected every day from intact female hamsters, ovariectomized hamsters and male hamsters.Male hamsters are housed in isolation and exposed to one of four conditions : intact female urine (female group), urine of ovariectomized females (OVX group), male hamster urine (male group), and distillled water (water group).After being reared for 15 days, the synapse in the female group is significantly greaterr than that in the water and the male groups.This indicates that exposure to female pheromones induces morphological changes in the synaptic size in the male AOB.

众所周知，脏层和尿液中含有输入物质。为了研究沃马纳索系​​统中的输入诱导的突触可塑性，已经在辅助嗅觉泡沫（AOB）（AOB）（AOB）中检查了污垢和尿液的影响。由雄性和女性大鼠（男性和女性组）弄脏的床上用品。另一个组仅被雄性（男性组）弄脏的床上用品。第三组暴露于干净的床上用品（清洁组）。在2个月中，男性和女性组的平均大小比男性的平均大小明显更大，而在男性中，男性的平均大小并不明显，而在男性中则显着，而在女性中则显着，而在男性中，在男性中的平均群体和女性群体相互介绍。表明，暴露于更复杂的污染床上用品环境可以引起男性大鼠AOB中突触的更大结构变化。（2）每天都会从每天从完整的女性仓鼠，卵巢剂量的汉姆斯特（Hamsters and Hamsters）的情况下，从事尿瘤的影响。 (female group), urine of ovariectomized females (OVX group), male hamster urine (male group), and distillled water (water group).After being reared for 15 days, the synapse in the female group is significantly greaterr than that in the water and the male groups.This indicates that exposure to female pheromones induces morphological changes in the synaptic size in the male AOB.

项目成果

Ichikawa M: "Neuronal development differentiation, and plasticity in the mammalian vomeronasal system." Zoolgical Science. (in press).

Ichikawa M：“哺乳动物犁鼻系统的神经发育分化和可塑性。”

Ichikawa M, Mastuoka M, Mori Y: "Plastic effect of soiled bedding on the structure of synapses in rat accessory olfactory bulb." Synapse. 21. 104-109 (1995)

Ichikawa M、Mastuoka M、Mori Y：“脏垫料对大鼠副嗅球突触结构的塑性影响。”

Ichikawa M, Matsuoka M, Mori Y: "Plastic effect of soiled bedding on the structure of synapses in rat accessory olfactory bulb." Synapse. 21. 104-109 ((1995))

Ichikawa M、Matsuoka M、Mori Y：“脏垫料对大鼠副嗅球突触结构的塑性影响。”

Ichikawa M,Mastuoka, M,Mori Y.: "Plastic effect of soiled bedding on the structure of synapses in rat accessory olfactory bulb." Synapse. 21. 104-109 (1995)

Ichikawa M、Mastuoka、M、Mori Y.：“脏垫料对大鼠副嗅球突触结构的塑料效应。”

Ichikawa M: "Neuronal development differentiation. and plasticity in the mammalian vomeronasal system." Zoolgical Science. (印刷中).

Ichikawa M：“哺乳动物犁鼻系统的神经发育分化和可塑性。”（正在出版）。