Research project on the varient modification of thermosensitivity in the

热敏性变体修饰研究项目

• 批准号: 04304029
• 负责人: KOSAKA Mitsuo
• 金额: $ 10.88万
• 依托单位: Institute of Tropical Medicine, Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04304029/
• 关键词: Thermosensitivity; thermotolerance; neuro-peptides; cytokine; neurotensin; Bombesin; IL-1alpha beta; heat shock protein(HSP); 温度修飾因子; 熱耐性; 熱感受性; 温熱細胞性免疫; 発熱・解熱; 寒冷・暑熱適応機序; 体温調節機序; SDS-PAGE,Western,Northan blotting

The present Research project on the varient modification of thermosensitivity in the cellular and bodily level is characterized by the interdisciplinary research fields that are composed of 8 Environmental physiologists, 3 Radiation Biologist, 2 Molecular Biologists and 3 Neuro-physiologists.1.The essential problems concerned with themosenstivity as well as with thermo-tolerance of cellular function were analyized from the view points of themoregulatory, febrile, sweating, immunological, endocrinological, cellular, and molecular biological levels.2.The thermoregulatory set-point and its modication of the varient neuro-peptides such like neurotensin, bombesin, neuropeptide Y.calcitonin gene-related peptide (CGRP) were reported by the present Environmental physiologists.3.Thermosensitivity and thermotolerance are modified not only by the above-mentioned neuropeptides but also the variant cytokines such like IL-1alpha beta, Heat Shock Proteins (HSP70,47), Quercetin(Suppressor of HSP induction) and LPS-pyrogen which were reported by radiation and molecular Biologists.

目前关于细胞和身体水平热敏性变化修饰的研究项目的特征是跨学科研究领域由8位环境生理学家，3名放射生物学家，2名分子生物学家和3个神经生理学家组成。1。从theSoregulatory，发热，出汗，免疫学，内分泌，细胞和分子生物学水平的观点分析了它们的细胞功能的热耐受性。 - 当前的环境生理学家报道了诸如神经素，孟买，孟买，神经肽Y.Calciton-基因相关肽（CGRP）的肽。3。耐皮菌和耐热性不仅受到上述神经肽的修饰，而且还通过上述神经肽进行了修饰。 -1alpha beta，热休克蛋白（HSP70,47），槲皮素（HSP诱导的抑制剂）和LPS-PYREGON，这些蛋白质由放射线和分子生物学家报道。

项目成果

Ohtsuka K.: "Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ." Blochem Biophys Res Comm. 197. 235-240 (1993)

Ohtsuka K.：“热休克蛋白 hsp40 的 cDNA 克隆，它是细菌 DnaJ 的人类同源物。”

黒島 晨汎 他: "非温熱性刺激による褐色脂肪組織内ガングリオシドGM_3の変化" 第70回日本生理学会大会予稿集. 294 (1993)

Akihiro Kuroshima 等人：“非热刺激导致棕色脂肪组织中神经节苷脂 GM_3 的变化”第 70 届日本生理学会年会论文集 294 (1993)。

小坂光男 他: "放射鼓膜温計の基本的・臨床的検討" 日生気誌. 29(2). 119-125 (1992)

Mitsuo Kosaka 等：“辐射鼓膜温度计的基础和临床研究”Nissei Kishi 29(2) 119-125 (1992)。

Kosaka,M.et al.: "High Altitude Medicine" ed by G.Ueda et al.,published by Shin Shu University Press Matsumoto,Japan, 546 (1992)

Kosaka,M.et al.：“高海拔医学”，G.Ueda 等人编辑，信州大学出版社出版，松本，日本，546 (1992)

Ohtsuka K.: "Effect of ATP on the release of hsp70 and hsp40 from the nucleus in heat-shocked HeLa cells." Exptl Cell Res. 209. 357-366 (1993)

Ohtsuka K.：“ATP 对热休克 HeLa 细胞细胞核中 hsp70 和 hsp40 释放的影响。”