Basic research on development of experimental animal model for weak heat tolerance and bbehavioral thermoregulation

弱耐热及行为体温调节实验动物模型建立的基础研究

• 批准号: 06557007
• 负责人: KOSAKA Mitsuo
• 金额: $ 11.84万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557007/
• 关键词: Pika; Ochotna; Thermal insulation; Thermal tolerance; hibernator; Telemetry; Body temperature; Skin hair; アフガン・ナキウサギ; クチグロ・ナキウサギ; テレメトリー; 乳酸値; 高体温; 血糖値; 日内リズム; 弱熱耐性; 行動性体温調節; 実験動物モデル; 寒冷ショック蛋白(CSP); 熱ショック蛋白(HSP); SDS-PAGE; Western Blo

(1) A Field Study of Telemetry-Recording of the Body Temperature in Wild Mongolian PikaThe pika inhabiting in cold zone or in high mountains is thought to be adapted to cold as well as high-altitude environment. We have reported pika's high body temperature (39.6ﾟC), high metabolism and poor heat loss ability such as poor lack of thermal salivation. In this study, we measured the body temperature of wild pikas (Ochotona daurica) with a telemetry device in their natural borrows in Mongolia. Two pikas captured at Under Dov were implanted with transmitters in the abdominal cavity under anesthesia, and were returned to the own habitat. The mean body temperatures of the pakas were 39.65ﾟC and and 39.96ﾟC,though the data were limited to a short period of less than one day. The present results in wild pikas support pika's high body temperature in our previous studies.(2) Anatomical observations and thermal tolerance in pika (Ochotona curzoniae)The heat insulations of chest and abdomen skin were inferior to back and waist. For pikas lying on their belly is a behavioral heat loss response. The high altitude adaptation of Pika in cold environment is due to heat conservation and heat production to be different from cold tolerance in hypothermia like as hibernator.

（1）对野生蒙古人体温进行遥测的现场研究，适用于寒冷以及高空环境。蒙古的自然借口在腹部麻醉中植入了两次捕获的长矛，并返回到自己的栖息地39.65°C。在野生皮卡（Pika）的pika温度不到一天，我们先前的研究（Ochotona curzoniae）的温度是胸部和腹部皮肤的腰部较低的。在冷环境中，皮卡的高海拔是热量的，与冬眠的低温耐受性不同。

项目成果

Kosaka, M.: Body Temperature and Metabolism. Ed.by T.Nagasaka and A.S.Milton IPEC (International Press Editing Center Incorporation) Tokyo, 234 (1995)

Kosaka, M.：体温和新陈代谢。

Kosaka,M.: "A new approach to analysis of human sweating" Experientia. 52(2). 131-135 (1996)

Kosaka,M.：“分析人体出汗的新方法”Experientia。

Kosaka,M.: "In Integrative and cellula spects of autonomic function: Temperature and osmoregulation" Ed. by Pleschka, R.Gersberger John Libbey Eurotext Paris, 554 (1994)

Kosaka,M.：“在自主神经功能的综合和细胞方面：温度和渗透调节”Ed。

Tsuchiya, K.: "Vasoconstriction induced by beta-adrenergic antagonist in the tail of chronic spinal rats." Tropical Medicine. 37(4). 175-183 (1995)

Tsuchiya, K.：“β-肾上腺素能拮抗剂在慢性脊髓大鼠尾部诱导血管收缩。”

小坂光男: "ナキウサギ(Pika)の弱熱耐性" 日本内分泌学会雑誌. 70(3). 89 (1994)

Mitsuo Kosaka：“鼠兔的耐热性较弱”，日本内分泌学会杂志 70(3) 89 (1994)。