Immigrant Study on CVD-related Dietary Factors in Japanese

日本人 CVD 相关饮食因素的移民研究

• 批准号: 04041073
• 负责人: NARA Yasuo
• 金额: $ 4.48万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04041073/
• 关键词: Immigrant Study; Dietary factors; Fish Intake Hypertension; Ischemic Heart Disease; Taurine; Unsaturated fatty acid; タウリン; 多価不飽和脂肪酸; 肥満度; コレステロール; ナトリウム; カリウム; カルシウム

Immigrant Study on CVD-related Dietary Factors in JapaneseObjective : To assess relationship of dietary factors to blood pressure (BP) and ischemic heart disease (IHD) among Japanese in Japan and Brazil.Design and Methods : 433 Japanese, aged 45 to 59, living in Japan (JJ)( Shimane (JS) and Okinawa (JO)) and 262 immigrants, aged 45 to 59, living in Brazil (JB)(Sao Paulo (BS) and Campo Grande (BC)) were recruited for BP measurement, 24 hours urine (24hu) collection, blood test, ECG at rest and medical history. Laboratory tests were centrally analyzed in the Izumo WHO collaborating center.Results : The JB showed higher body mass index, higher prevalence of hypercholesterolemia and of ischemic change in ECG (%)(BS : 3.8/4.1, BC : 7.9/9.6 vs JS : 2.0/2.0, JO : 3.3/4.2). The prevalence of hypertension (HT) (%) was higher in JB than in JJ (BS : 18.9/26.5, BC : 33.3/34.6 vs JS : 23.5/9.3, JO : 16.3/17.6). 24hu taurine (an index of sea food intake) excretion in both sexes and plasma phospholipid n-3 fatty acid level in men were significantly higher in JJ than in JB. The prevalence of diabetes mellitus (DM)(HbA1c>6%, %)(BS : 22.0/13.3, BC : 24.2/20.8 vs JS 3.7/0.0, JO 6.9/8.3) was also noted more frequently in JB than in JJ. A gradient in the frequency of meat intake was observed from JS to JO, BS and to BC and the opposite was found for fish intake. JB showed significantly higher rate of women who had used oral contraceptives than JJ.Conclusion : The dietary pattern in Japanese immigrants in Brazil, characterized by low fish intake and large meat intake, is possibly responsible for the higher risk of HT, DM and ECG ischemic changes, indicating possible beneficial effect of fish intake on prevention of cardiovascular disease.

日本观察者中与CVD相关饮食因素的移民研究：日本和巴西日本人中的饮食因素与血压（BP）和缺血性心脏病（IHD）的关系。设计和方法：433个日本人，年龄45至59岁，日本居住在日本（JJ）（jj）（JS）和Okinawa（js）和262（JJ）（JJ）（JJ）（JJ）（JJ）（JJ（JJ）（JJ）（JJ（JJ）（JJ）（JJ）（JJ）（JJ（JJ）（JJ）（JJ）（JJ（JJ）） （JB）（Sao Paulo（BS）和Campo Grande（BC））被招募进行BP测量，24小时尿液（24HU）收集，血液测试，静止和病史。实验室测试在合作中心的Izumo中进行了集中分析。溶剂：JB显示出更高的体重指数，高胆固醇血症的患病率较高以及ECG（％）（bs：3.8/4.1，bc：3.8/4.1，bc：7.9/9.6 vs js：2.0/2.0/2.0/2.0/2.0，JO：3.3/4.2）的ECG（％）（BS：3.8/4.4.1，BC：3.8/4.1）。 JB中高血压（HT）（％）的患病率高于JJ（BS：18.9/26.5，BC：33.3/34.6 vs JS：23.5/9.3，JO：16.3/17.6）。 JJ中男性和血浆磷脂N-3脂肪酸水平的24HU牛磺酸（海洋食品摄入指数）的排泄物在JJ中显着高于JB。糖尿病（DM）（HBA1C> 6％，％）的患病率（BS：22.0/13.3，BC：24.2/20.8 vs JS 3.7/0.0，JO 6.9/8.3）在JB中也更频繁地指出。从JS到JO，BS和BC观察到了肉类摄入频率的梯度，发现了相反的鱼类摄入量。 JB显示出使用口服避孕药的女性的率明显高于JJ。结论：巴西日本移民的饮食模式，其特征是鱼类摄入量低和肉类摄入量低，可能导致HT，DM和ECG缺血性更高的风险更高，表明对鱼类摄入的患者可能有益于心脏疾病的预防效果。

项目成果

Shunsaku Mizushima et al: "The Relationship of Dietary Factors to Cardiovascular Diseases among Japanese in Okinawa and Japanese Immigrants, originally from Okinawa, in Brazil." Hypertension Research. 15. 45-55 (1992)

Shunsaku Mizushima 等人：“冲绳日本人和来自巴西冲绳的日本移民的饮食因素与心血管疾病的关系。”

Y. YAMORI,: "World-wide epidemiological analysis on nutrition and stroke - A report from WHO CARDIAC STUDY." Second World Congress of Stroke. 110 (1992)

Y. YAMORI：“全球营养与中风流行病学分析 - 来自世界卫生组织心脏研究的报告。”

Y. YAMORI,: "International cooperarive study on the reltionship between dietary factors and blood pressure. A preliminary report from the CARDIAC Study." Nutrition and Health. 8. 77-90 (1992)

Y. YAMORI：“关于饮食因素与血压之间关系的国际合作研究。CARDIAC 研究的初步报告。”

Y. YAMORI,: "Dietary risk factors for high blood pressure - A report on ¨Core¨ WHO CARDIAC STUDY." J. Hypertens.10Suppl.4. 39 (1992)

Y. YAMORI，：“高血压的饮食危险因素 - 关于“核心”世界卫生组织心脏研究的报告。J. Hypertens.10Suppl.4 (1992)。