Effects of Vitamin D and Omega 3 Fatty Acids on Incidence Rate of Heart Failure

维生素 D 和 Omega 3 脂肪酸对心力衰竭发病率的影响

基本信息

批准号：
9900041
负责人：
LUC DJOUSSE
金额：
$ 72.11万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9900041
关键词：
Address Adult African American American Ancillary Study Calcium Cardiac Cardiovascular Diseases Cardiovascular system Cholecalciferol Data Death Rate Diabetes Mellitus Diagnosis Dietary intake Docosahexaenoic Acids Docosahexaenoic acid supplement Eicosapentaenoic Acid Event Expenditure Fish Oils Funding General Population Heart Rate Heart failure High Prevalence Hospitalization Hypertension Impairment Incidence Intervention Left Ventricular Function Left Ventricular Remodeling Left ventricular structure Low Prevalence Malignant Neoplasms Measures Medical Modification Myocardial Infarction Observational Study Olive oil preparation Omega-3 Fatty Acids Outcome Parents Participant Patients Placebos Population Postmenopause Prevalence Prevention strategy Prevention trial Primary Prevention Public Health Publishing Randomized Randomized Controlled Trials Recurrence Reporting Risk Risk Factors Role Sample Size Secondary Prevention Serum Specific qualifier value Stains Testing Therapeutic Time Treatment Failure United States National Institutes of Health Ventricular Remodeling Vitamin D Vitamin D Deficiency Woman Women&apos s Health Work adjudicate base clinical practice cost cost effective delta opioid receptor design dietary supplements efficacy testing follow-up hemodynamics high risk improved interest men mortality mortality risk novel novel strategies older women outcome forecast prevent primary endpoint randomized trial

项目摘要

Abstract Heart failure (HF) expenditure amounts to several billion per year. Despite advances in medical treatment of HF, mortality after HF onset and rate of recurrent HF decompensation remain high, underscoring an urgent need to identify effective prevention strategies. Observational studies showed a higher risk of death in HF patients with lower levels of vitamin D and two recent post-hoc analyses of trials conducted in mostly post- menopausal women reported a reduction in HF rates in the vitamin D group compared with placebo. Vitamin D has also been reported to improve hemodynamics and left ventricular remodeling in 229 HF patients. However, no randomized trial has examined the effects of vitamin D on primary prevention of HF or on the rate of recurrent HF decompensation in men and women. Efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on cardiovascular events has been reported in trials with low prevalence of stain use only. EPA/DHA can reduce risk factors for HF including myocardial infarction, hypertension, and diabetes. While some but not all observational studies have suggested an inverse association between EPA/DHA and the incidence of HF, no large primary prevention trial of EPA/DHA on HF has been conducted. In addition, effect modification of the effects of EPA/DHA on HF by statin has not been elucidated. This project will investigate the effects of vitamin D and EPA/DHA supplements on the incidence rate of HF and on recurrent HF decompensation in an ancillary study of the VITamin D and OmegA-3 TriaL (VITAL), an NIH-funded randomized controlled trial of 25,874 men and women testing the efficacy of 2,000 IU/day cholecalciferol and 1 g/day EPA/DHA on cardiovascular disease and cancer endpoints.

抽象的心力衰竭（HF）每年的支出为数十亿。尽管在医疗方面取得了进步 HF，HF发作后的死亡率和复发性HF代偿率仍然很高，突显了紧急的需要确定有效的预防策略。观察性研究表明，HF死亡风险更高维生素D含量较低的患者和两次事后分析的试验后，大多数情况下进行了试验更年期妇女报告说，与安慰剂相比，维生素D组的HF率降低。维生素d 据报道，还可以改善229例HF患者的血液动力学和左心室重塑。然而，尚无随机试验检查维生素D对HF初级预防的影响或男性和女性反复发作的HF代理。 eicosapentaenoic（EPA）和在染色率低的试验中，据报道了心血管事件的二十六六烯酸（DHA）（DHA）仅使用。 EPA/DHA可以减少HF的危险因素，包括心肌梗塞，高血压和糖尿病。虽然一些但并非所有观察性研究都表明EPA/DHA与 HF的发生率未进行HF的大型主要预防试验。此外，尚未阐明汀类药物对EPA/DHA对HF的影响的影响。这个项目将研究维生素D和EPA/DHA补充剂对HF发病率和反复的影响在维生素D和Omega-3试验的辅助研究中，HF代偿性是由NIH资助的 25,874名男性和女性的随机对照试验测试了2,000 IU/天胆固醇和1个的功效 G/天EPA/DHA关于心血管疾病和癌症终点。