NMR console (replacement) for 500 MHz spectrometer

用于 500 MHz 光谱仪的 NMR 控制台（替换件）

• 批准号: 507275896
• 金额: --
• 依托单位: Rheinische Friedrich-Wilhelms-Universität Bonn
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2022
• 资助国家: 德国
• 起止时间: 2021-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/507275896?language=en
• 关键词: NMR; console; replacement; 500; MHz

The NMR laboratory in the platform "Chemical Analysis" at the Pharmaceutical Institute of the University of Bonn is responsible for the processing of numerous NMR spectroscopic questions. The existing 500 MHz NMR spectrometer is a mainstay of NMR analysis in the Department of Pharmacy. The instrument is essential for all research projects of the research groups utilizing synthetic organic chemistry and is used for structure elucidation and characterization of small molecules, peptidomimetics, proteolysis-targeting molecules (PROTACs), macrocycles and natural products, among others. Spare parts for the existing console are no longer available and the replacement of the console is inevitable. Furthermore, the replacement of the control unit is necessary to provide a modern user-friendly operation. Currently, the 500 MHz NMR spectrometer still has to be shimmed "by hand". Therefore, the NMR console replacement, the replacement of probehead and a software upgrade are expected to significantly economize and increase the efficiency of NMR analysis. The existing 500 MHz instrument is very heavily utilized due to the high number of NMR samples and a failure would have a dramatic impact on the research results of the Department of Pharmacy. Therefore, the modernization of the existing 500 MHz NMR spectrometer is requested.

波恩大学药学院“化学分析”平台的核磁共振实验室负责处理众多核磁共振波谱问题。现有的 500 MHz NMR 波谱仪是药学系 NMR 分析的支柱。该仪器对于利用合成有机化学的研究小组的所有研究项目都是必不可少的，可用于小分子、肽模拟物、蛋白水解靶向分子 (PROTAC)、大环化合物和天然产物等的结构阐明和表征。现有控制台的备件不再可用，更换控制台是不可避免的。此外，为了提供现代化的用户友好型操作，需要更换控制单元。目前，500 MHz 核磁共振波谱仪仍然需要“手动”调整。因此，核磁共振控制台的更换、探头的更换和软件升级预计将显着节省并提高核磁共振分析的效率。现有的500 MHz仪器由于核磁共振样本数量较多，使用率非常高，一旦出现故障就会对药学系的研究结果产生巨大影响。因此，需要对现有 500 MHz NMR 波谱仪进行现代化改造。