Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in

使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型，以分析白细胞介素 17 抑制剂的细胞和表观遗传效应

• 批准号: 2890513
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2027
• 资助国家: 英国
• 起止时间: 2027 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2890513
• 关键词: Developing; 3D; printed; skin; model

There are now a wealth of treatments for psoriasis (Ps), a chronic non contagious autoimmune skin disease usually arising in inflamed red and white scaly patches of skin. Ps has no known cure but symptoms can be controlled by treatments such as steroid creams and UV light. Ps affects 2-3 % of the population and 125million people worldwide. Although biological therapeutics have revolutionised the treatment of disease, there is still a significant proportion of patients that fail to respond, patients that relapse and long term, drug free remission is not readily achievable. There is evidence how skin from Ps patients is differentially methylated compared to that of healthy skin, with the implication that this methylation may maintain keratinocytes in a hyper-inflammatory state. Long term treatment response may therefore be dependent on the control of this methylation state.

现在有大量的牛皮癣治疗（PS），这是一种慢性非传染性自身免疫性皮肤疾病，通常在发炎的红色和白色鳞片皮肤上引起。 PS没有已知的治愈方法，但是症状可以通过类固醇霜和紫外线等治疗方法来控制。 PS在全球范围内影响2-3％的人口和1.55亿人口。尽管生物学治疗剂彻底改变了疾病的治疗，但仍有很大一部分无法反应的患者，复发和长期的患者，无药物缓解不容易实现。有证据表明，与健康皮肤相比，PS患者的皮肤如何被差异化甲基化，这意味着这种甲基化可以使角质形成细胞保持在过度炎症状态。因此，长期治疗反应可能取决于对这种甲基化状态的控制。