FACTORS IMPLICATED IN THE DEVELOPMENT AND RECURRENCE

与发展和复发有关的因素

• 批准号: 12557134
• 负责人: TAKETANI Yuji
• 金额: $ 8.32万
• 依托单位: THE UNIVERSITY OF TOKYO
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12557134/
• 关键词: angiogenesis; endometriosis; cytokine; peritoneal fluid; IP-10; p38MAPK; マウス子宮内膜症モデル; インターロイキン16; IP10; SCF; soluble TNF receptor

To date, numerous soluble substances have been demonstrated to be present at different concentrations with or without endometriosis. We revealed that Stem cell factor (SCF) concentration in PF is increased in women with enodmetriosis. The concentrations of SCF in PF tended to decrease with the progression of endometriosis. SCF is known to stimulate mast cell functions. In view of human endometrium having SCF receptors, it can be speculated that SCF in PF may affect fertility of women with early stages of endometriosis by modulating functions of mast cells and/or endometrial cells. We also detected the increase of sTNFRI and sTNFRII concentrations in PF of women with endometriosis. The increase may stimulate the development of endometriosis, as these soluble molecules may antagonize TNFα mediated apoptosis of endometriotic cells. We further demonstrated that IP-10 concentrations in PF were significantly lower in women with advanced stages of endometriosis as compared to those with early stages. Decreased concentrations of IP-10 in PF from women with advanced stages of endometriosis may imply that the peritoneal environment of these women is permissive to the development of the disease by enhancing angiogenesis and/or modulating inflammatory/ immunological responses.

迄今为止，已证明在患有或不患有子宫内膜异位症的情况下，多种可溶性物质以不同的浓度存在。我们发现，患有子宫内膜异位症的女性中，PF 中的干细胞因子 (SCF) 浓度有所增加。已知 SCF 会刺激肥大细胞功能，鉴于人类子宫内膜具有 SCF 受体，因此可以推测 PF 中的 SCF 可能会影响早期女性的生育能力。我们还检测到子宫内膜异位症女性 PF 中 sTNFRI 和 sTNFRII 浓度的增加，这种增加可能会刺激子宫内膜异位症的发展，因为这些可溶性分子可能会拮抗 TNFα 介导的子宫内膜异位症细胞凋亡。我们进一步证明，与早期子宫内膜异位症女性相比，晚期子宫内膜异位症女性 PF 中的 IP-10 浓度显着降低。子宫内膜异位症晚期女性的 PF 中 IP-10 浓度降低可能意味着这些女性的腹膜环境通过增强血管生成和/或调节炎症/免疫反应而允许疾病的发展。

项目成果

Koga K, Osuga Y, Tsutsumi O, et al.: "Demonstration of angiogenin in human endometrium and its enhanced expression in endometrial tissues in the secretory phase and the decidua"J Clin Endocrinol Metab. 86・11. 5609-5614 (2001)

Koga K、Osuga Y、Ttsutsumi O 等：“人子宫内膜中血管生成素及其在分泌期和蜕膜中的子宫内膜组织中增强表达的证明”J Clin Endocrinol Metab 86・11（2001）。

Fujimoto A, Osuga Y, Fujiwara T, Yano T, Tsutsumi O, Momoeda M, Kugu K, Koga K, Morita Y, Wada O, Taketani Y.: "Human Chorionic Gonadotropin Combined with Progesterone for Luteal Support Improves Pregnancy Rate in Patients with Low Late-Midluteal Estradio

Fujimoto A、Osuga Y、Fujiwara T、Yano T、Ttsutsumi O、Momoeda M、Kugu K、Koga K、Morita Y、Wada O、Taketani Y.：“人绒毛膜促性腺激素联合黄体酮支持黄体可提高妊娠率

Osuga Y, Koga K, et al: "Transwarld Research Network Local regulators of the human ovary in associated reproductive technology"(ART)in Recent Research Development in Endocrinology. 3. 349-357 (2002)

Osuga Y、Koga K 等人：“Transwarld 研究网络相关生殖技术中人类卵巢的局部调节器”(ART)，《内分泌学最新研究进展》。

Kurosawa T, Hiroi H, Tsutsumi O, Ishikawa T, Osuga Y, Fujiwara T, Inoue S, Muramatsu M, Momoeda M, Taketani Y.: "The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type"Endocr J.. 49. 465-71 (2002)

Kurosawa T, Hiroi H, Tsutsumi O, Ishikawa T, Osuga Y, Fujiwara T, Inoue S, Muramatsu M, Momoeda M, Taketani Y.：“双酚 A 的活性取决于雌激素受体亚型和细胞类型”Endocr

Fujimoto A, Osuga Y, Yano T, Kusumi M, Kurosawa T, Fujii T, Taketani Y.: "Ovarian hyperstimulation syndrome complicated by peritonitis due to perforated appendicitis Case Report"Hum Reprod. 17. 966-967 (2002)

Fujimoto A、Osuga Y、Yano T、Kusumi M、Kurosawa T、Fujii T、Taketani Y.：“卵巢过度刺激综合征并发阑尾炎穿孔所致腹膜炎病例报告”Hum Reprod。