The role of the basal ganglia in the bruxism and the development of the method for that estimation

基底神经节在磨牙症中的作用及其估计方法的开发

• 批准号: 10557164
• 负责人: MASUDA Yuji
• 金额: $ 6.78万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10557164/
• 关键词: electrical stimulation; mastication; putamen; dopamine; 6OHDA; intake behavior; 大脳基底核; 被核; 淡蒼球; 咀嚼筋; イボテン酸; ウサギ; 大脳基底核咀嚼; 単一神経活動

It is still unknown how the bruxism are occurred and how the brain is involved in the bruxism. The aim of this project was to clarify the role of the basal ganglia in the bruxism. For this purpose we first examined whether the bruxism was able to be evoked experimentally or not, and secondly how the basal ganglia was involved in the oral function. Unfortunately we could not induce the bruxism either by stimulation to the basal ganglia or by making the basal ganglia lesion. Concerning the relationship between the mastication and the basal ganglia and also the nigrostriatal dopaminergic pathway, we obtained the findings in this study as follows ;1) It has been known that the masticatory sequence in the rabbit can be divided into three stages (stage I, IIa, IIb) based on the form of the jaw movements. It is found that electrical stimulation to the basal ganglia during stage II modulated the jaw movements. This result suggested that the basal ganglia might be involved in the alteration of the jaw movements according to the progress of masticatory sequence.2) Using the microdialysis method, the dopamine concentration in the putamen increased significantly during mastication compared with resting period. And the bilateral 6-hydroxydopamine lesions of the nigrostriatal dopaminergic pathway induced the change of the movement pattern during intake behavior. These results suggested that the nigrostriatal dopaminergic pathway might play a role in the sequential progress during the mastication.In this study, we showed the data, which suggested the basal ganglia might play a role in the control of orofacial fuctional behavior. We hope that our findings will be useful for the experiments studying the mechanism of the bruxism in the future.

仍然未知磨牙症是如何发生的，以及大脑如何参与磨牙症。该项目的目的是阐明基底神经节在磨牙症中的作用。为此，我们首先检查了是否能够通过实验诱发磨牙症，其次是基底神经节如何参与口服功能。不幸的是，我们无法通过刺激基底神经节或使基底神经节病变诱导磨牙症。关于咀嚼与基底神经节之间的关系以及骨纹状体多巴胺能途径，我们在这项研究中获得的发现如下：1）众所周知，兔子中的咀嚼序列可以根据JAW的运动形式分为三个阶段（I期，IIA，IIB）。发现在II期期间向基底神经节的电刺激调节了下颌运动。该结果表明，根据咀嚼序列的进展，基底神经节可能参与下颌运动的改变。2）使用微透析方法，与静止期相比，在咀嚼期间，壳质的多巴胺浓度显着增加。黑质纹状体多巴胺能途径的双侧6-羟基多巴胺病变诱导了摄入行为过程中运动模式的变化。这些结果表明，黑质多巴胺能途径可能在咀嚼过程中的顺序进展中起作用。在这项研究中，我们展示了数据，这表明基底神经节可能在控制口面相比行为中起作用。我们希望我们的发现将对研究未来的磨牙症机制的实验有用。

项目成果

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Martin, R.E.、Kemppainen, P.、Masuda, Y.、Yao, D.、Murray, G.M. 和 Sessle, B.J.：“清醒灵长类动物（食蟹猴）皮质诱发吞咽的特征。”J.神经生理学.. 82。

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松尾，R.

Hidaka,O. et al.: "Influence of clenching intensity on bite force balance, occlusal contact area, and average bite pressure."J.Dent.Res.. 78. 1336-1344 (1999)

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Kato, T., Masuda, Y., Hidaka, O., Komuro, A., Inoue, T.and Morimoto, T.: "Characteristics of the muscle spindle endings of the masticatory muscles in the rabbit under halothane anesthesia."Brain Res.. 833. 1-9 (1999)

Kato, T.、Masuda, Y.、Hidaka, O.、Komuro, A.、Inoue, T. 和 Morimoto, T.：“氟烷麻醉下兔子咀嚼肌肌梭末端的特征。”

Funahashi,M. et al.: "Propagation of synchronous burst discharges from entorhinal cortex to morphologically and electrophysiologically identified neurons of rat lateral amygdala."Brain Res.. 884. 104-115 (2000)

船桥，M.