Role of the neural network of the brain stem in the inhibition of the rhythmical jaw movements

脑干神经网络在抑制有节奏的下颌运动中的作用

• 批准号: 16591856
• 负责人: MASUDA Yuji
• 金额: $ 2.3万
• 依托单位: Matsumoto Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591856/
• 关键词: mastication; jaw movement; brain stem; cortical masticatory area

It has been known that electrical stimulation to the focal area in the brain stem inhibits the rhythmical jaw movements (RJMs) evoked by repetitive stimulation to the cortical masticatry area (CMA). However, the physiological significance of that area has not been clarified. First, the neural network involved in the inhibitory effect on the RJMs was investigated in the rabbit using neuro-tracing methods. The inhibitory area was identified in the reticular formation adjacent to the periaqueductal gray matter. Injection of the anterograde tracer biocytine or retrograde tracer fluoro-gold was in this area conformed by the inhibitory effect. Labeled terminals by biocytine were found in the medial pontine reticular nucleus, and labeled cell by fluoro-gold was also found in the medial pontine reticular nucleus. This suggests that the reciprocal connection between the reticular formation adjacent to the periaqueductal gray matter and the medial pontine reticular nucleus may involved in the inhibitory effect on RJMs. Second, in order to know the feature of cortically induced RJMs, we investigated the cortico-striatal pathway from the CMA of the rabbit with electrophysiology and anatomical technique. Evoked potentials by stimulation to the CMA were recorded from the ventral part of the putamen. Injection of biocytine to the CMA resulted in that labeled terminals were located in the ventral part of the putamen. It is suggested that the ventral part of the putamen may involved in the control of masticatory movements.

众所周知，对脑干焦点区域的电刺激会抑制由于对皮质咀嚼区（CMA）重复刺激而引起的有节奏的下颌运动（RJM）。然而，该区域的生理意义尚未阐明。首先，使用神经追踪方法在兔子身上研究了参与 RJM 抑制作用的神经网络。在邻近导水管周围灰质的网状结构中确定了抑制区域。在该区域注射顺行示踪剂生物胞素或逆行示踪剂氟金与抑制作用一致。桥脑内侧网状核中发现生物胞素标记的末端，桥脑内侧网状核中也发现荧光金标记的细胞。这表明邻近导水管周围灰质的网状结构与桥脑内侧网状核之间的相互联系可能参与了对 RJM 的抑制作用。其次，为了了解皮质诱导的RJMs的特征，我们利用电生理学和解剖学技术研究了兔子CMA的皮质纹状体通路。从壳核的腹侧部分记录刺激 CMA 引起的诱发电位。向 CMA 注射生物胞素导致标记末端位于壳核的腹侧部分。这表明壳核的腹侧部分可能参与咀嚼运动的控制。

项目成果

Serotonin suppresses evoked EPSPs in superficial layers neurons of rat trigeminal caudal nucleus.

血清素抑制大鼠三叉神经尾核浅层神经元诱发的 EPSP。

• 发表时间: 2006
• 期刊: Dentistry in Japan (in press)
• 作者: Kobayashi M;Takemura M;Kang Y
• 通讯作者: Kang Y

Comparisons between excitatory and inhibitory mechanisms on jaw-closing motoneurons.

闭颌运动神经元的兴奋性和抑制性机制的比较。

• 发表时间: 2005
• 期刊: Dentistry in Japan 41
• 作者: Takemura M;Sugiyo S;Moritani M;Kobayashi M;Yonehara N.;Shigenaga Y;Takemura M;Moritani M
• 通讯作者: Moritani M

The distribution of inhibitory and excitatory synapses on single, reconstructed jaw-opening motoneurons in the cat.

猫的单个重建的张口运动神经元上的抑制性和兴奋性突触的分布。

• 发表时间: 2005
• 期刊: Neuroscience 133
• 作者: Takemura M;Sugiyo S;Moritani M;Kobayashi M;Yonehara N.;Shigenaga Y;Takemura M;Moritani M;Ambalavanar R;Bae YC;Shigenaga Y
• 通讯作者: Shigenaga Y

Bilateral projection of functionally characterized trigeminal oralis neurons to trigeminal motoneurons in cats.

猫功能特征三叉神经口神经元向三叉运动神经元的双边投射。

• 发表时间: 2005
• 期刊: Brain Research 1036
• 作者: Ambalavanar R;Moritani M;Moutanni A;Gangula P;Yallampalli C;Dessem D.;Ambalavanar R;Abe T;Yoshida A
• 通讯作者: Yoshida A

Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensorynucleus : 1

消除尾核中的神经激肽-1受体神经元可逆转全身性荷包牡丹碱对大鼠三叉神经感觉核中c-Fos表达的影响：1

• 发表时间: 2005
• 期刊: Neuroscience 133・3
• 作者: Abe;T.et al.
• 通讯作者: T.et al.