The role of raphe nuclei in regulating sexual behavior in rats.

中缝核在调节大鼠性行为中的作用。

• 批准号: 05640756
• 负责人: YAMANOUCHI Korehito
• 金额: $ 1.28万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05640756/
• 关键词: Sexual behavior; Dorsal raphe nucleus; Median raphe nucleus; Serotonergic neuron; Inhibitory system; lordosis; Sexual differentiation; Rats; マウント; 中脳縫線核; セロトニン; PCPA; プロゲステロン; 抑制神経機構; 神経線維切断; エストロゲン; 中脳背側縫線核; 中隔

In this experiment, the role of the dorsal raphe nucleus and the median raphe nucleus in regulating female and male sexual behavior was investigated in rats.In the conclusion, the dorsal raphe nucleus but not median raphe nucleus plays an inhibitory role in regulation of lordosis behavior (female sexual behavior) in male rats. The inhibition for lordosis is exerted by serotonergic neurons in the dorsal raphe nuclues and is sent by the neural fibers which leave from the anterovental area of the nucleus to the forebrain. Furthermore, the function of the dorsal raphe nuclues is independent on an another inhibitory system in the lateral septum. The inhibition of lordosis by GABAergic neurons is dependent on the function of the dorsal raphe nucleus.The median raphe nuclues has an inhibitory role in regulating ejaculatory behavior in male rats. In female rats, the median raphe nucleus also exert inhibitory influence in ragualtion for male sexual behavior. However, the dorsal raphe nucleus is not essentian for the regualtion of male sexual behavior.

本实验研究了中缝背核和中缝核在调节雌性和雄性性行为中的作用。结论是，中缝背核而不是中缝核对脊柱前凸行为的调节具有抑制作用。 （雌性性行为）在雄性大鼠中。对脊柱前凸的抑制是由中缝背核中的血清素能神经元发挥的，并由从核的前腹区发出到前脑的神经纤维发送。此外，中缝背核的功能独立于侧隔膜中的另一个抑制系统。 GABA能神经元对脊柱前凸的抑制依赖于中缝背核的功能。中缝核对雄性大鼠的射精行为具有调节抑制作用。在雌性大鼠中，中缝核对雄性性行为的调节也具有抑制作用。然而，中缝背核对于男性性行为的调节并不是必需的。

项目成果

Kondo, Y.and Yamanouchi, K.: "The possible involvement of the nonstrial pathway of the amygdala in neural control of sexual behavior in male rats." Brain Res.Bull.38(1). 37-40 (1995)

Kondo, Y. 和 Yamanouchi, K.：“杏仁核的非纹状体通路可能参与雄性大鼠性行为的神经控制。”

Kondo, Y., Yamanouchi, K.and Arai, Y.: "P-chlorophenylalanine facilitates copulatory behavior in septal lesioned but not in preoptic lesioned male rats." J.Neuroendocrinol.5(6). 629-633 (1993)

Kondo, Y.、Yamanouchi, K. 和 Arai, Y.：“对氯苯丙氨酸促进间隔损伤的交配行为，但不会促进视前损伤的雄性大鼠的交配行为。”

Kakeyama, M.and Yamanouchi, K.: "Female sexual behaviors in male rats with dorsal raphe nucleus : Treatment with p-chlorophenylalanine." Brain Res.Bull.30(5/6). 705-709 (1993)

Kakeyama, M. 和 Yamanouchi, K.：“中缝背核雄性大鼠的雌性性行为：对氯苯丙氨酸治疗。”

山内兄人 新井康充: "性行動-ラットの実験を中心として" 新医科学大系・脳と行動. 10. 79-100 (1994)

山内兄弟，新井康光：“性行为 - 关注大鼠实验”新医学科学研究所，大脑和行为。10. 79-100 (1994)

Kondo, Y., Koizumi, T., Arai, Y., Kakeyama, M.and Yamanouchi, K.: "Functional relationships between mesencephalic central gray and septum in regulating lordosis in female rats : Effect of dual lesions" Brain Res.Bull.32(6). 635-638 (1993)

Kondo, Y.、Koizumi, T.、Arai, Y.、Kakeyama, M. 和 Yamanouchi, K.：“中脑中央灰质和隔膜在调节雌性大鼠脊柱前凸方面的功能关系：双重病变的影响”Brain Res.Bull