Lordosis inhibiting systems in the septum and dorsal raphe nucle-us

隔膜和中缝背核的脊柱前凸抑制系统

基本信息

批准号：
09680802
负责人：
YAMANOUCHI Korehito
金额：
$ 0.7万
依托单位：
Waseda University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09680802/
关键词：
Lordosis Inhibition Septum Dorsal Raphe Nucleus Sexual Differentiation Estrogen Serotonergic Neuron Neural Transection Rats ロードーシス抑制力

项目摘要

The lateral septum (LS) exerts an inhibitory influence in regulation of female characteristic sexual behavior, such as lordosis and soliciting behavior in both female and male rats. The inhibitory mechanism also exist in the serotonergic neurons in the dorsal raphe nucleus (DRN). In male rats, these female sexual behavioral patterns are very rare, even when treated with large doses of estrogen. The low incidence of female sexual behavior in males is thought to be cased by strong inhibitory influences in the LS and DRN.In this experiment, these inhibitory mechanisms have been analyzed by neuroendocrinological methods and following results were obtained. 1 : Since the ventral cut of the anterior part of the DRN enhanced lordotic behavior in both male and female rats, anteroventral projections of this nucleus are involved in lordosis inhibitory mechanisms. 2 : Female levels of lordotic activity was induced by transection of the medial forebrain bundle in male rats. This suggests an importance of the bundle as a pathway for lordosis inhibiting influence. 3 : To clarify the role of estrogen in the inhibitory systems of the LS and DRN, estradiol was implanted directly in these areas and lordosis was observed in subthreshold doses of estradiol benzoate-injected castrated female and male rats. As a result, estrogen implanted in the LS butnot in the DRN facilitated lordosis in female rats. This result indicates that the inhibition for lordosis in the LS is released directly by estrogen but not in the DRN.Furthermore, implantation of estrogen into the LS in males had no effect on lordosis. Thus, the reason of low incidence of female sexual behavior in male rats is the development of strong inhibition in the LS which can not be released directly by estrogen.

侧隔（LS）对女性特征性行为的调节产生了抑制作用，例如女性和男性大鼠的脊柱和征求行为。抑制性机制也存在于背侧raphe核（DRN）中的血清素能神经元中。在雄性大鼠中，即使用大剂量的雌激素治疗，这些女性性行为模式也很少见。人们认为，女性性行为在LS和DRN中的强烈抑制作用被认为是壳的。在本实验中，这些抑制性机制已通过神经内分泌学方法进行了分析，并获得了以下结果。 1：由于雄性和雌性大鼠的DRN前部的腹侧切割，因此该细胞核的前腹腹突变参与了脊柱叶抑制机制。 2：女性水平的脊柱质活性是通过雄性大鼠内侧前脑束的横切引起的。这表明束的重要性是抑制影响力的脊柱障碍的途径。 3：为了阐明雌激素在LS和DRN的抑制系统中的作用，将雌二醇直接植入了这些区域，并在雌二醇苯二甲酸酯苯甲酸酯注射的cast骨cast骨和雄性大鼠中观察到了脊柱。结果，雌激素植入了LS丁并在雌性大鼠的DRN中促进的Lordosis。该结果表明，LS中脊柱肌的抑制作用直接由雌激素释放，但不能在DRN中释放。Furthermore，将雌激素植入雄性中的LS中没有对脊柱虫的影响。因此，雄性大鼠女性性行为发生率低的原因是LS中强烈抑制的发展，而LS无法直接释放出雌激素。