Study of diabetic maculopathy by focal lmacular ERG

局灶黄斑ERG研究糖尿病性黄斑病变

• 批准号: 04454440
• 负责人: MIYAKE Yozo
• 金额: $ 3.71万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454440/
• 关键词: Focal macular ERG; Diabetic macularpatting; Layr-by-layr analysis; inner layr; outer layr; Diabetic macular edema; Oscillatory Potentials; 糖尿病網膜症; 黄斑浮腫; 層別診断; 先天網膜分離; 類のう胞黄斑浮腫; 中心性漿液性脈絡網膜症; 無水晶体性黄斑浮腫; 糖尿病性黄斑症; α波; b波

We have succeeded to record a-wave, b-wave and oscillatory potentials (OPs) in human macular region, using the focal amcular ERG recording system developed by us. The analysis of these components can provide the layr-by-layr diagnosis of the macular diseases. The purpose of this study is to investigate the pathogenesis of the diabetic maculopathy with this system. Before analylzing diabetic maculopathy, we studied the inner layr disease (congenital retinoschisis and aphakic cystoid macular edema) and outer retinal disease (central serous chorioretinopathy) to know the properties of focal macular ERG in theses known diseases. The results indicated that in outer retinal disease, all components of ERG were deteriorated, even when the visual acuity was relatively good. On the othger hand, in inner retinal diseases, the OPs were the most sensitively deteriorated, followed by the deteriration of the b-wave and a-wave. In diabetic macular edema, the focal macular ERG showed combined onner and outer retinal layr disturbance in many patients, indicating that the edema excists not only in the inner retinal layr, but also in the outer retinal layr.

我们已经成功地使用了美国开发的局灶性Amcular ERG记录系统来记录人类黄斑区域的A波，B波和振荡电位（OP）。这些成分的分析可以提供黄斑疾病的逐层诊断。这项研究的目的是研究该系统的糖尿病性刺病发病机理。在分析糖尿病性糖尿病性糖浆病毒之前，我们研究了内部疾病（先天性视网膜菌和蚜虫囊性黄斑水肿）和视网膜外部疾病（中央浆膜脉络毒素病），以了解已知疾病中局灶性黄斑ERG的特性。结果表明，在视网膜外疾病中，即使视力相对较好，ERG的所有成分也会恶化。在视网膜内部疾病中，在Othger的手上，OPS是最敏感的恶化，其次是B波和A波的恶化。在糖尿病性黄斑水肿中，局灶性黄斑ERG在许多患者中表现出组合的视网膜和外部视网膜外层障碍，表明水肿不仅在视网膜内部层中有所不同，而且在视网膜外层中也有所不同。

项目成果

Miyake Y,Miyake K et al: "Classification of aphakic cystoid macular edema with focal macular electroretinograms" Am J Ophthalmol. 116. 576-583 (1993)

Miyake Y、Miyake K 等人：“通过局灶性黄斑视网膜电图对无晶状体囊样黄斑水肿进行分类”Am J Ophthalmol。

Miyake Y,Shiroyama N et al: "Focal macular electro retinogram in x-linked congenital retinoschisis" Invest Ophthalmol Vis Sci. 34. 512-515 (1993)

Miyake Y、Shiroyama N 等人：“x 连锁先天性视网膜劈裂中的局灶性黄斑视网膜电图”Invest Ophthalmol Vis Sci。

Miyake Y, Awaya S et al: "Hyperbaric oxygen and acetazolamide imporve visual acuity in cystoid macular edema with different mechanisms." Arch Ophethalmol. 111. 1605-1606 (1993)

Miyake Y、Awaya S 等人：“高压氧和乙酰唑胺通过不同的机制改善黄斑囊样水肿的视力。”

Miyake Y, Miyake K and Shiroyama N.: "Clasification of aphakec cystoid macular edema with focal macular electroretinogram." Am J Ophthalmol. 116. 576-583 (1993)

Miyake Y、Miyake K 和 Shiroyama N.：“无晶状体黄斑囊样水肿与局灶性黄斑视网膜电图的分类。”

Miyake Y, Shiroyama N, Ota I, and Horiguchi M.: "Focal macular electroretinogram in X-linked congenital retinoschisis." Invest Ophthalmol Vis Sci. 34. 512-515 (1993)

Miyake Y、Shiroyama N、Ota I 和 Horiguchi M.：“X 连锁先天性视网膜劈裂中的局灶性黄斑视网膜电图”。