Objective visual functions in macular diseases

黄斑疾病的客观视觉功能

基本信息

批准号：
62480362
负责人：
MIYAKE Yozo
金额：
$ 4.29万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480362/
关键词：
focal macular ERG oscillatory potentials foveal cone densitometry layer-by-layer objective methods central serous chorioretinopathy selective reduction of oscillatory potentials 律動様小波経年変化糖尿病性黄斑症 Retinal Densitometry 錐体視物質局所ERG /

项目摘要

The studies of focal macular ERG have been made with special reference to its suitable recording condition and functional properties by using fundus monitoring system in human. By improving the signal to noise ratio, we successfully recorded the oscillatory potentials (OPs) in addition to a-wave, b-wave and, offresponse in human macular region. The distribution of OPs in relation to those in a-wave and b-wave was studied. The amplitude of a-wave, b-wave and OPs of the upper macular region was significantly larger than that of lower macular region.The changes of amplitude in response to the spot size and ring stimuli indicated that the distribution of OPs is relatively sparse in the fovea, and it becomes relatively more dense than those of a-wave and b-wave from the fovea toward the parafovea, and even more strikingly toward the perifovea. There was no statistical difference of amplitude in both a-wave and b-wave between temporal and nasal macula. However, the amplitude of OPs in tempor … More al macula was significantly larger than that in nasal macula. we studied several macular diseases with focal macular ERG in terms of a-wave, b-wave, off-responses and OPs. In some macular diseases, such as diabetic maculopathy, c)(stoid macular edema or convalescent stage of idiopathic central serous chorioretinopathy, the macular OPs were selectively reduced, leaving the a-wave and b-wave intact. The macular OPs can be a sensitive indicator to assess the macular function in several macular diseases.We built a prototype apparatus for foveal cone densitometry that combined a modified fundus camera, independent optic pathways, and a personal computer.Using a two-way density technique, the density and regeneration time of the foveal cone pigment can be measured objectively: Foveal cone densitometry may elucidate some aspects of macular pathology that cannot be ascertained by psychophysical or electrophysiological techniques.By combining these two methods, layer-by-layer analysis of macular diseases can be performed by objectively measured visual functions. Less

利用人体眼底监测系统，特别参考其合适的记录条件和功能特性，对局灶性黄斑ERG进行了研究，通过提高信噪比，我们成功记录了除了a-之外的振荡电位（OP）。研究了人黄斑区的 OP 相对于 a 波和 b 波的分布。上黄斑的 a 波、b 波和 OP 的幅度。光斑大小和环刺激的振幅变化表明，OPs在黄斑中心凹的分布相对稀疏，并且比a波和环刺激的分布相对密集。 b 波从中央凹到中央凹，更明显的是到中央凹周围颞黄斑和鼻黄斑之间的 a 波和 b 波振幅没有统计学差异。颞黄斑明显大于鼻黄斑，我们研究了几种具有局灶性黄斑 ERG 的黄斑疾病，包括 a 波、b 波、无反应和 OP。 c)(黄斑水肿或特发性中心性浆液性脉络膜视网膜病变恢复期，黄斑OP选择性减少，留下a波和b 波完好无损，黄斑 OP 可以作为评估多种黄斑疾病的黄斑功能的敏感指标。我们构建了一个用于黄斑视锥细胞光密度测量的原型设备，该设备结合了改良的眼底相机、独立的光学通路和个人计算机。双向密度技术，可以客观地测量中心凹锥体色素的密度和再生时间：中心凹锥体密度测量可以阐明黄斑病理学的某些方面，而这些方面是无法通过通过心理物理学或电生理学技术来确定。通过结合这两种方法，可以通过客观测量的视觉功能来对黄斑疾病进行分层分析。