Study of the mechanism of visual function in incomplete type of congenital stationary night blindness

不完全型先天性静止性夜盲症视功能机制研究

基本信息

批准号：
06454496
负责人：
MIYAKE Yozo
金额：
$ 2.94万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454496/
关键词：
CSNB Complete type Incomplete type rod bipolar cell rod b-wave STR SRCI Locus of night blindness 不全型停止性夜盲完全型停止性夜盲杆体錐体干渉現象フリッカー光錐体、杆体干渉現象デンシイトメトリー

项目摘要

We studied the mechanism of visual function in complete and incomplete type of congenital stationary night blindness (CSNB) with the following results.1.Locus of night blindnessUsing full-field stimuli with light intensities ranging from near absolute threshold to bright, ERG intensity series from patients with complete and incomplete CSNB and from normal subjects were recorded. Neither the rod b-wave nor the STR was recordable from patients with complete CSNB.In the incomplete CSNB,the STR was clearly recordable, although the absolute threshold was elevated slightly. The b-wave stimulus threshold was not elevated, and the b-wave amplitude near threshold was normal. The peak time of the STR was delayd by approximately 80 msec, whereas that of b-wave was normal.Above results suggest that the locus of the night blindness of the complete type may lie in the rod bipolar cell, while that of incomplete type may lie proximal to the rod bipolar cell.2.Rod-cone interactionDark-adapted rods have a suppressive effect on cone response (SRCI). This phenomenon was applied to analyze the pathological mechanism of CSNB.Our results indicated that SRCI is normal in both complete and incomplete CSNB,but in some cases, SRCI is absent because of localized retinal dysfunction.

我们研究了完全型和不完全型先天性静止性夜盲症（CSNB）的视觉功能机制，得到了以下结果。 1.夜盲症的轨迹使用光强度从接近绝对阈值到明亮的全视野刺激，ERG强度系列从记录完全和不完全CSNB 患者以及正常受试者。完全性CSNB患者的杆状b波和STR均无法记录。在不完全性CSNB中，STR清晰可记录，尽管绝对阈值略有升高。 b波刺激阈值未升高，阈值附近的b波幅度正常。 STR波峰时间延迟约80毫秒，而b波正常。以上结果提示，完全型夜盲症的病灶可能位于视杆双极细胞，不完全型夜盲症的病灶可能位于杆状双极细胞。 2. 视杆-视锥细胞相互作用暗适应视杆细胞对视锥反应（SRCI）有抑制作用。应用这一现象来分析CSNB的病理机制。我们的结果表明，在完全性和不完全性CSNB中，SRCI都是正常的，但在某些情况下，由于局部视网膜功能障碍，SRCI不存在。