Study of the mechanism of visual function in incomplete type of congenital stationary night blindness

不完全型先天性静止性夜盲症视功能机制研究

基本信息

批准号：
06454496
负责人：
MIYAKE Yozo
金额：
$ 2.94万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454496/
关键词：
CSNB Complete type Incomplete type rod bipolar cell rod b-wave STR SRCI Locus of night blindness 不全型停止性夜盲完全型停止性夜盲杆体錐体干渉現象フリッカー光錐体、杆体干渉現象デンシイトメトリー

项目摘要

We studied the mechanism of visual function in complete and incomplete type of congenital stationary night blindness (CSNB) with the following results.1.Locus of night blindnessUsing full-field stimuli with light intensities ranging from near absolute threshold to bright, ERG intensity series from patients with complete and incomplete CSNB and from normal subjects were recorded. Neither the rod b-wave nor the STR was recordable from patients with complete CSNB.In the incomplete CSNB,the STR was clearly recordable, although the absolute threshold was elevated slightly. The b-wave stimulus threshold was not elevated, and the b-wave amplitude near threshold was normal. The peak time of the STR was delayd by approximately 80 msec, whereas that of b-wave was normal.Above results suggest that the locus of the night blindness of the complete type may lie in the rod bipolar cell, while that of incomplete type may lie proximal to the rod bipolar cell.2.Rod-cone interactionDark-adapted rods have a suppressive effect on cone response (SRCI). This phenomenon was applied to analyze the pathological mechanism of CSNB.Our results indicated that SRCI is normal in both complete and incomplete CSNB,but in some cases, SRCI is absent because of localized retinal dysfunction.

我们研究了具有以下结果的完整和不完整类型的先天性静态夜失明（CSNB）的视觉功能的机制。1。夜间盲目的全场刺激的局限性，其光强度从绝对阈值接近绝对阈值到明亮的ERG强度，来自正常受试者和正常受试者的患者的ERG强度系列，记录了正常受试者的患者。杆B波和STR都不是完全CSNB的患者记录的。在不完整的CSNB中，STR显然是可记录的，尽管绝对阈值略有升高。 B波刺激阈值没有升高，接近阈值的B波振幅正常。 The peak time of the STR was delayd by approximately 80 msec, whereas that of b-wave was normal.Above results suggest that the locus of the night blindness of the complete type may lie in the rod bipolar cell, while that of incomplete type may lie proximal to the rod bipolar cell.2.Rod-cone interactionDark-adapted rods have a suppressive effect on cone response (SRCI).该现象用于分析CSNB的病理机制。您的结果表明，SRCI在完整和不完整的CSNB中都是正常的，但是在某些情况下，由于局部的视网膜功能障碍而缺乏SRCI。