Research of Microactuators Applied to Intravascular Microvehicles

应用于血管内微载体的微执行器研究

• 批准号: 01870104
• 负责人: FUJIMASA Iwao
• 金额: $ 49.92万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01870104/
• 关键词: Micromachine; Microactuator; Silicon Process; Microfabrication; LPCVD; RIE; Artificial Sarcomea; Hybrid Microsensor; 生体適合性; エネルギ-伝達; 医療応用; 運動機構; 組織適合性; 抗血栓性

The project was aimed at developing micromachines for intravascular use itself and their designing and fabrication technologies. The project is the first trial for producing the micromachine in medicine and also establishing the first micromachine center in the medical engineering research. The project was started on September, 1988, and built a micromachine fabrication system where silicon process and photolithography technology became applicable. In the system, a silicon wafer of 2 inch diameter can be used, and sarcomere like integrated microactuators has been developed. For machining and assembling microparts in the three dimensional space, a micromanipulation system and a three axial machining system were intoduced and many microparts were produced. A micro artificial heart valve in millimeter size has been developed with the system. For developing intravascular machines, we have applied laser angioplasty systems, which were developed another biomedical project The micro-intravascular vehicles with tethers has been designed and been assembled. Under the pathway of these development, we found a new microactualer designing principle, and its theroretical background has been studied.

该项目旨在开发用于血管内使用本身及其设计和制造技术的微机械。该项目是第一个生产医学微机械的试验，并且还建立了医学工程研究中的第一个微电学中心。该项目始于1988年9月，建立了一个微型制造系统，硅过程和光刻技术变得适用。在系统中，可以使用直径为2英寸的硅晶片，并且已经开发了像集成的微抗体器一样。为了在三维空间中的加工和组装微型车，进行了微观计量系统和三个轴向加工系统，并产生了许多微型车。该系统已经开发了一个微型人造心脏阀。为了开发血管内机器，我们应用了激光血管成形术系统，该系统是开发了另一个生物医学项目的，该项目的微型内血管车辆已设计和组装。在这些发展的途径下，我们发现了一种新的微观设计原理，并且已经研究了其具有理论的背景。

项目成果

Fujimasa, I.: "Medical Paradigm Change by Micromachine Technology" BME (Bio Medical Engineering). 3(1). 2-7 (1989)

Fujimasa, I.：“微机械技术改变医学范式”BME（生物医学工程）。

Iwao Fujimasa: "Medical Applications of Micromachine Technology" Technical Digest of the 8th Sensor Symposium. 135-139 (1989)

Iwao Fujimasa：《微机械技术的医疗应用》第八届传感器研讨会技术文摘。

藤正 巖: "生体とマイクロマシン" 電子情報通信学会誌. 74. 936-939 (1991)

Iwao Fujimasa：“生物体和微型机器”电子、信息和通信工程师学会杂志 74. 936-939 (1991)。

藤正 巖: "驚異の医療機械マイクロマシン" 講談社, 214 (1990)

岩生藤正：“神奇的医疗微型机器”讲谈社，214（1990）

藤正 巖: "マイクロマシンは医学をどのように変えうるか" BME. 3. 2-7 (1989)

Iwao Fujimasa：“微型机器如何改变医学”BME。3. 2-7 (1989)