In situ cross-linking hydrogels for regeneration of cartilage

原位交联水凝胶用于软骨再生

• 批准号: 283823407
• 负责人: Professor Dr. Steffen Fischer
• 金额: --
• 依托单位: Institut für Pflanzen- und Holzchemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/283823407?language=en
• 关键词: situ; cross; linking; hydrogels; regeneration

In situ cross-linking hydrogels are useful for minimal invasive treatment of tissue defects and also for controlled release of drugs. The proposal is focused on the hypothesis that semisynthetic sulfated and oxidized polysaccharides based on cellulose and chitosan can be used for generation of hydrogels with tunable mechanical properties, degradation behavior, kinetic of release of growth factor TGF-beta 3 and resulting chondrogenic activity towards mesenchymal stem cells to be applicable for regeneration of cartilage. Beside synthesis of cellulose and chitosan derivatives, characterization of mechanical degradation properties and in vitro studies on bioactivity, also spectroscopic and imaging methods shall be used to analyze mass transfer inside hydrogels, mechanical properties and biocompatibility in vitro and in vivo with a mouse model.

原位交联的水凝胶可用于最小化组织缺陷的侵入性治疗，也可用于控制药物的释放。该提议的重点是假设，即基于纤维素和壳聚糖的半合成硫化和氧化的多糖含量可用于生成具有可调机械性能的水凝胶，降解行为，生长因子TGF-beta 3的释放的动力学，以及可用于培训的软骨源性活性，适用于培养物的小软骨源。除了纤维素和壳聚糖衍生物的合成外，机械降解特性的表征以及对生物活性的体外研究还应使用光谱和成像方法来分析水凝胶，机械性能，机械性能，与小鼠模型的体外和体内生物相容性。

项目成果

Effect of Sulfation Route and Subsequent Oxidation on Derivatization Degree and Biocompatibility of Cellulose Sulfates.

硫酸化路线和随后的氧化对硫酸纤维素衍生化程度和生物相容性的影响

• DOI: 10.1002/mabi.201900403
• 发表时间: 2019
• 期刊: Macromolecular bioscience
• 影响因子: 4.6
• 作者: J. Strätz;A. Liedmann;T. Heinze;S. Fischer;T. Groth
• 通讯作者: T. Groth

Development of hydrogels based on oxidized cellulose sulfates and carboxymethyl chitosan

基于氧化纤维素硫酸盐和羧甲基壳聚糖的水凝胶的开发

• DOI: 10.1007/s10570-019-02596-6
• 发表时间: 2019
• 期刊: Cellulose
• 影响因子: 5.7
• 作者: J. Strätz;A. Liedmann;M.-L. Trutschel;K. Mäder;T. Groth;S. Fischer
• 通讯作者: S. Fischer

Hydrogels Based on Oxidized Cellulose Sulfates and Carboxymethyl Chitosan: Studies on Intrinsic Gel Properties, Stability, and Biocompatibility.

基于氧化纤维素硫酸盐和羧甲基壳聚糖的水凝胶：凝胶固有特性、稳定性和生物相容性研究

• DOI: 10.1002/mabi.202100098
• 发表时间: 2021
• 期刊: Macromolecular bioscience
• 影响因子: 4.6
• 作者: C. Willems;M.-L. Trutschel;V. Mazaikina;J. Strätz;K. Mäder;S. Fischer;T. Groth
• 通讯作者: T. Groth

Synthesis and Characterization of Oxidized Polysaccharides for In Situ Forming Hydrogels

• DOI: 10.3390/biom10081185
• 发表时间: 2020-08-01
• 期刊: BIOMOLECULES
• 影响因子: 5.5
• 作者: Muhammad, Muhammad;Willems, Christian;Groth, Thomas
• 通讯作者: Groth, Thomas

Tailored covalently cross-linked hydrogels based on oxidized cellulose sulfate and carboxymethyl chitosan by targeted adjustment of the storage modulus

通过有针对性地调整储能模量，定制基于氧化纤维素硫酸盐和羧甲基壳聚糖的共价交联水凝胶

• DOI: 10.1007/s10570-020-03279-3
• 发表时间: 2020
• 期刊: Cellulose
• 影响因子: 5.7
• 作者: J. Strätz;S. Fischer
• 通讯作者: S. Fischer