I-Corps: A Minimally Invasive Palpation Device for Intraoperative Tumor Detection

I-Corps：用于术中肿瘤检测的微创触诊设备

• 批准号: 2325222
• 负责人: Jinho Kim
• 金额: $ 5万
• 依托单位: Stevens Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2024-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2325222&HistoricalAwards=false
• 关键词: Corps; Minimally; Invasive; Palpation; Device

The broader impact/commercial potential of this I-Corps project is the development of intraoperative robotic palpation device that can significantly improve the outcome of cancer treatment. A major problem that our device intends to solve is that tumors with sub-centimeter in their size are difficult to identify via preoperative imaging and during minimally invasive intraoperative procedures. Our robotic palpation device can be deployed into the patient’s body and quickly generate a tissue stiffness map at the pathologic region with a high spatial resolution. By enabling precise and prompt detection of tumors, regardless of their size, this technology can significantly enhance the outcomes of tumor resection surgery. This technology has a wide range of potential applications beyond intraoperative tumor detection. It has the capability to identify diseased tissues, including fibrotic tissues, whose physical characteristics have undergone alterations. Altogether, this cutting-edge technology has the unparalleled ability to identify diseased tissues, providing invaluable quantitative information to empower clinicians to confidently make data-driven decisions about the most effective treatment strategies. This I-Corps project is based on the development of a robotic palpation device that can help surgeons to detect tumors during minimally invasive robot-assisted cancer treatment surgery. In open chest surgery, surgeons frequently rely on manual palpation to detect tumors that may not be visible on imaging techniques, such as X-ray, CT, or MRI, especially those small than 1 cm. However, a persistent technical challenge involving the robot-assisted surgery is the surgeon’s inability to touch and feel the tissues during the surgery. As a result of the surgeon’s loss of tactile sensation, small tumors can remain undetected, leading to incomplete tumor removal that can cause cancer progression, recurrence, and metastasis. This innovation is a “robotic finger” that can be deployed into the patient’s body during surgery and survey the pathologic tissue areas to generate a tissue stiffness map that is correlated to the presence of tumorous tissues that must be removed surgically. This innovation will offer surgeons the ability to pinpoint all tumors with substantially improved accuracy and resolution, ultimately leading to improved patient outcomes and a reduction in cancer recurrence and metastasis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是开发术中机器人手掌装置，可以显着改善癌症治疗的结果。我们的设备打算解决的一个主要问题是，在术前成像以及在最小侵入性的术中手术过程中，很难识别出次级中心的肿瘤。我们的机器人手掌装置可以部署到患者体内，并在病理区域迅速产生组织刚度图，并具有高空间分辨率。通过使肿瘤的精确检测和迅速检测，无论其大小如何，该技术都可以显着增强肿瘤切除手术的结果。该技术在术中肿瘤检测外具有广泛的潜在应用。它具有鉴定患病组织的能力，包括纤维化组织，其物理特征发生了改变。总的来说，这项尖端的技术具有识别溶液的无与伦比的能力，提供了宝贵的定量信息，以增强临床医生的能力，以确保对最有效的治疗策略做出数据驱动的决策。这个I-Corps项目基于机器人手掌装置的开发，该设备可以帮助外科医生在微创机器人辅助癌症治疗手术中检测肿瘤。在开放式手术中，外科医生经常依靠手动触诊来检测在成像技术（例如X射线，CT或MRI）上可能看不见的肿瘤，尤其是小于1 cm的肿瘤。但是，涉及机器人辅助手术的持续技术挑战是外科医生在手术过程中无法接触和感受组织。由于外科医生失去触觉感觉，小肿瘤可能仍未发现，导致肿瘤清除不完全，可能导致癌症进展，复发和转移。这项创新是一种“机器人手指”，可以在手术过程中部署到患者的身体中，并调查病理组织区域，以产生与必须通过手术去除的肿瘤时机相关的组织刚度图。这项创新将使外科医生能够以大大提高准确性和分辨率来查明所有肿瘤，最终导致患者的结果改善，并减少癌症复发和转移。该奖项反映了NSF的法定任务，并被认为是通过使用该基金会的知识分子和更广泛影响的评估来审查Criteria来通过评估来通过评估来获得支持的。

项目成果

A Minimally Invasive Robotic Tissue Palpation Device

• DOI: 10.1109/tbme.2024.3357293
• 发表时间: 2024-06-01
• 期刊: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
• 影响因子: 4.6
• 作者: Mir，Mohammad;Chen，Jiawen;Kim，Jinho
• 通讯作者: Kim，Jinho