CAREER: Biomechanics of Tension-Induced Lung Tissue Fracture and Subsequent Pulmonary Air Leak

职业：张力引起的肺组织骨折和随后的肺漏气的生物力学

• 批准号: 2143620
• 负责人: Jinho Kim
• 金额: $ 57.61万
• 依托单位: Stevens Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2143620&HistoricalAwards=false
• 关键词: CAREER; Biomechanics; Tension; Induced; Lung; CAREER; Biomechanics; Tension; Induced; Lung

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2).This Faculty Early Career Development (CAREER) award will support research to investigate how soft lung tissue can be injured by mechanical ventilation. This work will also study tissue injury that can lead to air leak in the lungs. Mechanical ventilation has been a life-saving therapy for many clinical complications. This research will use an engineering approach to better understand the biophysical characteristics of lung tissue that undergoes prolonged mechanical ventilation. First, this work will study the relationship between the strength of lung tissue and injuries caused by air leak. Second, this work will use acoustics to quantify the severity of air leak injuries. This work is important because how the lung tissue responds to repeated air pressure loading remains poorly understood. It is known that lung tissue can be damaged and torn due to repeated forceful stretching of the lung during mechanical ventilation. Through the damaged tissue, inhaled air can leak into the chest cavity and cause respiratory failure. The results of this work can ultimately help minimize lung injury during mechanical ventilation. The work will benefit society by generating fundamental insights into how lung tissue behaves. It will also facilitate the development of innovative technologies. Further, this research will be integrated with education to provide student-centered STEM experiences to local minority students. The overall research goal of this project is to understand how the intrinsic deformation mechanics of the lung is altered dynamically in response to repeated overdistension, and how the alternation is linked to tension-induced fracture of soft lung tissue that can lead to pulmonary air leak. Accordingly, this project will investigate quantifiable characteristics of lung tissue fracture and subsequent air leak to provide a set of comprehensive explanations for the biomechanics of tension-induced lung tissue injury. This study is organized under two research objectives: 1) determining the impacts of mechanical properties of lung tissue on initiation, propagation, and resolution of lung tissue fracture during mechanical ventilation; and 2) identifying acoustic characteristics of air leak sound generated via dynamic airflow-tissue interaction to evaluate the role of acoustic signal as a quantifiable indicator of air leak injury. Successful completion of the study will generate new knowledge that can provide fundamental insights into non-linear deformation and fracture mechanics of soft lung tissue, ultimately offering improved diagnosis, treatment, and prevention of tension-induced lung injury. Further, the work will allow the PI to initiate an impactful and sustainable research career in lung mechanics, and become an educator who is dedicated to mitigating learning barriers for underrepresented minority students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项是根据2021年《美国救援计划法》的全部或部分资助的（公共法117-2）。这项教师的早期职业发展（职业）奖将支持研究，以调查如何通过机械通风来伤害软肺组织。这项工作还将研究可能导致肺部空气泄漏的组织损伤。机械通气一直是许多临床并发症的救生疗法。这项研究将采用工程方法更好地了解经历延长机械通气的肺组织的生物物理特征。首先，这项工作将研究肺组织强度与空气泄漏引起的伤害之间的关系。其次，这项工作将使用声学来量化空气泄漏伤害的严重程度。这项工作很重要，因为肺组织如何应对反复的气压负荷响应仍然鲜为人知。众所周知，由于机械通气过程中肺部反复伸展，肺组织可能会损坏和撕裂。通过受损的组织，吸入空气会渗入胸腔并引起呼吸衰竭。这项工作的结果最终可以帮助最大程度地减少机械通气期间的肺损伤。这项工作将通过对肺组织的表现产生基本见解，从而使社会受益。它还将促进创新技术的发展。此外，这项研究将与教育相结合，以向当地少数民族学生提供以学生为中心的STEM经验。 该项目的总体研究目标是了解肺的内在变形力学如何因重复过度差而动态地改变，以及如何将交替与软肺组织的张力诱导的断裂有关，从而导致肺部空气泄漏。因此，该项目将研究肺组织断裂的可量化特征和随后的空气泄漏，以为张力引起的肺组织损伤的生物力学提供一系列的全面解释。这项研究是在两个研究目标下组织的：1）确定肺组织机械性能对机械通气过程中肺组织骨折起始，传播和分辨率的影响； 2）确定通过动态气流 - 组织相互作用产生的空气泄漏声的声学特征，以评估声学信号作为可量化的空气泄漏损伤指标。该研究的成功完成将产生新知识，可以为软肺组织的非线性变形和断裂力学提供基本见解，最终提供改进的诊断，治疗和预防张力引起的肺损伤。此外，这项工作将使PI能够在肺部力学上发起有影响力的可持续研究职业，并成为一名致力于减轻代表性不足的少数民族学生的学习障碍的教育者。这项奖项反映了NSF的法定任务，并通过使用该基金会的知识分子优点和广泛的影响来评估NSF的法定任务，并被视为值得的支持。