I-Corps: Translation Potential of a Minimally Invasive Continuum Surgical Robot for the Eye/Ear

I-Corps：眼/耳微创连续手术机器人的翻译潜力

• 批准号: 2420989
• 负责人: David Usevitch
• 金额: $ 5万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2420989&HistoricalAwards=false
• 关键词: Corps; Translation; Potential; Minimally; Invasive

The broader impact of this I-Corps project is the development of a minimally invasive, robotic, surgical device for specialized procedures in the eye and ear. A delivery system that can more accurately navigate to the subretinal space has the potential to more safely and efficiently deliver and accurately position a stem cell sheet (or other therapeutic medium) in the eye. Accurate and safe delivery could lead to improvements in retinal degenerative diseases (which affect over 400 million people worldwide) making the procedure simpler and faster. The device also holds the potential for improved steering of cochlear implants or other therapeutics into the cochlea for restoring hearing loss. The ideal device would become a surgical tool for minimally invasive surgical steering maneuvers around the world. This I-Corps project utilizes experiential learning coupled with a first-hand investigation of the industry ecosystem to assess the translation potential of the technology. The solution is based on the development of a minimally invasive device made up of a disposable continuum manipulator for steering through anatomy, and a handle which can be either held or mounted. Various prototypes have been constructed and tested in various phantom mediums, such as gels and replicated three-dimensional printed anatomy. The device has also been mounted on other robotic arms for use as an end-effector manipulator in some of these tests. The device is being tested in animal cadaver models and further development is underway for refinement and improved steering characterization.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响是开发一种微创，机器人，手术装置，用于眼睛和耳朵中的专门手术。可以更准确地导航到视网膜下空间的输送系统具有更安全有效地输送并准确地将干细胞板（或其他治疗培养基）放置在眼睛中的潜力。准确且安全的交付可能会导致视网膜退行性疾病的改善（全球超过4亿人），从而使该过程更加简单，更快。该设备还具有改善耳蜗植入物或其他治疗剂转向耳蜗的潜力，以恢复听力损失。理想的设备将成为世界各地最小侵入性手术转向动作的手术工具。这个I-Corps项目利用体验式学习以及对行业生态系统的第一手研究来评估技术的翻译潜力。该解决方案基于由一次性连续操作器组成的微创装置的开发，用于通过解剖结构进行转向，以及可以固定或安装的手柄。已经在各种幻影培养基（例如凝胶和复制的三维印刷解剖结构）中构建和测试了各种原型。该设备还安装在其他机器人臂上，以用作这些测试中的最终效应器操纵器。该设备正在动物尸体模型中进行测试，并正在进行进一步的开发以进行改进和改进的转向表征。该奖项反映了NSF的法定任务，并且使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估来提供支持。