I-Corps: minimally invasive deep brain stimulation using temporally interfering electromagnetic waves

I-Corps：使用时间干扰电磁波进行微创深部脑刺激

• 批准号: 2328599
• 负责人: Behnaam Aazhang
• 金额: $ 5万
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2328599&HistoricalAwards=false
• 关键词: Corps; minimally; invasive; deep; brain

The broader impact/commercial potential of this I-Corps project is that it aims to restore the autonomy of patients with Parkinson's disease by improving their physical well-being, easing the costs associated with caregiving, and preventing the loss of employment. The current approach to treating medication-resistant Parkinson's disease, called Deep Brain Stimulation, requires electrode implantation inside the brain tissue that creates potential for surgical complications like intracranial hemorrhage or stroke. The proposed project provides a minimally-invasive way to stimulate the brain continuously. The stimulation device is best suited for treating patients with Parkinson's disease due to its continuously operable and portable nature. The technology may also effectively treat disorders like essential tremor, epilepsy, and depression, which are traditional candidates for deep brain stimulation surgery. This methodology can open a new chapter in neuromodulation technologies by offering benefits not shared by prior methodologies of electrical stimulation. This could have a huge social impact as, according to the Parkinson’s Foundation, there are 10 million Parkinson's disease patients globally. Specifically, one million patients in the US live with Parkinson's disease, and nearly 90,000 patients are diagnosed with Parkinson's disease yearly. In the US, the healthcare costs associated with Parkinson's disease are estimated to be $52 billion a year.This I-Corps project is based on the development of brain stimulation implants that use the superposition of two similar giga-hertz electromagnetic waves, transmitted by endocranially implanted antenna arrays, for creating a low-frequency envelop signal to stimulate deep brain targets in a highly focused, and yet minimally invasive fashion. The stimulation is based on the following key factors: i) GHz EM waves can be radiated very effectively using antennas, a mature and cost-effective technology. Since the size of an antenna is inversely proportional to the operating frequency, one can use very small antennas at GHz frequencies. (ii) Multiple single antennas can be grouped together to create an antenna array. The higher the number of antennas in an array, the narrower the stimulating beams becomes, penetrating deeper into the brain tissue. (iii) Due to the small wavelength of GHz EM waves, the stimulation offers twice the degrees-of-freedom as prior brain stimulation technologies to achieve focal brain stimulation. (iv) Additionally, one can stimulate multiple targets inside the brain tissue without changing the location of the antenna arrays. This is significantly more flexible than state-of-the-art invasive electrodes for brain stimulation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的广播公司影响/商业潜力是，它旨在通过改善其身体健康，减轻与护理相关的成本并防止失业丧失，恢复帕金森氏病患者的自主权。当前治疗耐药帕金森氏病的方法称为深脑刺激，需要在脑组织内部植入电极，从而为手术并发症（如颅内出血或中风）创造了潜力。拟议的项目提供了一种最小的侵入性方法来连续刺激大脑。该仿真装置最适合治疗帕金森氏病患者，因为其持续可操作和便携性。该技术还可以有效地治疗诸如必需树，癫痫和抑郁症之类的疾病，这些疾病是深脑刺激手术的传统候选者。该方法可以通过提供先前的电刺激方法所共有的益处来打开神经调节技术的新章节。根据帕金森基金会的说法，这可能会产生巨大的社会影响，全球有1000万帕金森氏病患者。具体来说，美国一百万患者每年都患有帕金森氏病，近90,000名患者被诊断出患有帕金森氏病。在美国，与帕金森氏病相关的医疗保健费用估计为每年520亿美元。此I-Corps项目基于大脑刺激的发展，使用了两个类似的Giga-Hertz电磁波的叠加，该项目通过近距离植入的天线阵列，以启用刺激性的刺激性启动，以实现刺激性的刺激性启动，以产生刺激性的启动，以创建一个较高的刺激性。侵入性时尚。刺激基于以下关键因素：i）GHz EM波可以使用天线（一种成熟且具有成本效益的技术）非常有效地放射放射。由于天线的大小与工作频率成反比，因此可以在GHz频率下使用非常小的天线。 （ii）可以将多个单个天线分组在一起以创建天线阵列。阵列中天线的数量越高，刺激梁的变窄越狭窄，深入到脑组织中。 （iii）由于GHz EM波的小波长，该刺激提供了两倍的自由度，作为先前的大脑刺激技术，以实现局灶性脑刺激。 （iv）此外，一个人可以刺激脑组织内部的多个靶标，而不会改变天线阵列的位置。这比用于脑刺激的最新侵入性电极要灵活得多。该奖项反映了NSF的法定任务，并通过使用基金会的知识分子优点和更广泛的影响审查标准来评估被认为是宝贵的支持。