Minimally invasive quantitative tissue oxygen sensors to personalize cancer care

微创定量组织氧传感器实现个性化癌症护理

• 批准号: 10698650
• 负责人: Gregory Ekchian
• 金额: $ 39.99万
• 依托单位: STRATAGEN BIO, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-14 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10698650
• 关键词: Aftercare; Anatomy; Animal Model; Animals; Benign Prostatic Hypertrophy; Biochemical; Brachytherapy Seeds; Canis familiaris; Cervical; Clinical; Clinical Data; Clinical Trials; Data; Devices; Dimensions; Dose; Effectiveness; Environment; Evaluation; Formulation; Foundations; Gases; Grant; Head and Neck Cancer; Head and neck structure; Health; Human; Hypoxia; Image; Immunotherapy; Innovation Corps; Interview; Lead; Literature; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of cervix uteri; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Measurement; Measures; Methods; Modeling; Monitor; Mus; Nature; Oncology; Outcome; Oxygen; PC3 cell line; Patient-Focused Outcomes; Patients; Performance; Phase; Physiological; Pilot Projects; Polymers; Prostate; Radiation Dose Unit; Radiation therapy; Resistance; Resolution; Rodent Model; Science; Silicones; Site; Small Business Innovation Research Grant; Testing; Tissues; Trauma; Validation; Visual; Work; arm; biomaterial compatibility; chemotherapy; design; good laboratory practice; implantation; improved outcome; in vivo; malignant breast neoplasm; mechanical properties; migration; minimally invasive; mortality; personalized cancer care; personalized medicine; preclinical evaluation; programs; prostate cancer model; prostate enlargement; sensor; targeted treatment; technology validation; treatment planning; trend; tumor; tumor hypoxia

Project Summary and Abstract Hypoxic (oxygen depleted) tumors are more resistant to treatments including radiation therapy. This trend has been seen across a wide range of cancers including prostate, head and neck, and cervical. Radiobiological studies have shown that elevated radiation doses can be used to overcome hypoxia-induced resistance and achieve the same level of effectiveness as lower doses in more well-oxygenated environments. The major impediment to implementing this (and other) hypoxia targeting therapies is the lack of a suitable oxygen sensor. Actionable oxygen sensors should be quantitative, workflow compatible, and provide spatial context for each measurement. Current and past alternatives for oxygen sensing are either qualitative, too invasive, or both. The proposed oxygen sensor will offer a workflow-compatible method to obtain quantitative tumor oxygen data. The sensor is measured non-invasively using MRI which provides a spatial/anatomical context for each measurement. The sensor is made completely of silicone, inserted with minimally invasive methods, equilibrates quickly with the surrounding tissue, and is fully reversible. The polymeric nature of the material allows it to remain at the site of insertion indefinitely to enable long-term monitoring. The proposed work focuses on selection of a lead formulation (Aim 1), evaluation in a small animal tumor model (Aim 2), and evaluation in a large animal model to mimic the tissue volumes expected during human use (Aim 3). The sensor produced as part of this proposal will be translatable to additional applications in oncology, but also to non-oncology applications including tissue health and trauma.

项目摘要和摘要 缺氧（氧气耗尽）肿瘤对包括放射治疗在内的治疗更具耐药性。这个趋势有 在包括前列腺，头颈和颈椎在内的广泛癌症中看到。放射生物学 研究表明，升高的辐射剂量可用于克服缺氧诱导的耐药性和 在更氧合的环境中，达到与较低剂量相同的有效性。专业 实施这种（和其他）靶向疗法的障碍是缺乏合适的氧气传感器。 可操作的氧气传感器应定量，工作流程兼容，并为每个传感器提供空间上下文 测量。当前和过去的氧气传感替代方法要么是定性的，过于侵入性或两者兼而有之。这 拟议的氧气传感器将提供与工作流兼容的方法，以获取定量的肿瘤氧数据。这 使用MRI对传感器进行非侵入性测量，该MRI为每种提供空间/解剖环境 测量。该传感器完全由硅胶制成，用微创方法插入，平衡 迅速使用周围的组织，并且是完全可逆的。材料的聚合性质使其可以保持 在插入的位置无限期地进行长期监控。拟议的工作着重于选择 铅配方（AIM 1），小动物肿瘤模型中的评估（AIM 2）和大动物的评估 模拟人使用过程中预期的组织体积的模型（AIM 3）。传感器作为其中的一部分生产 提案将转换为肿瘤学的其他应用，也可以转化为非综合性应用程序 包括组织健康和创伤。