Novel Implementation of Microporous Annealed Particle HydroGel for Next-generation Posterior Pharyngeal Wall Augmentation

用于下一代咽后壁增强的微孔退火颗粒水凝胶的新实现

• 批准号: 10727361
• 负责人: James J. Daniero
• 金额: $ 32.3万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10727361
• 关键词: 3-Dimensional; Acute; Address; Advanced Development; Aerodigestive Tract; Affect; Aftercare; Anatomy; Animal Model; Biocompatible Materials; Biomedical Engineering; Blood Vessels; Calcium; Clinical; Collaborations; Collagen; Data; Dermis; Detection; Durapatite; Environment; Failure; Filler; Foreign-Body Reaction; Fostering; Functional disorder; Future; Gel; Goals; Growth; Hyaluronic Acid; Hydrogels; Immune; Implant; In Situ; Inflammation; Injectable; Injections; Light; Magnetic Resonance Imaging; Methodology; Methods; Microspheres; Modeling; Modernization; Molecular Conformation; Movement; Muscle; Operative Surgical Procedures; Oryctolagus cuniculus; Otolaryngology; Outcome; Outcome Assessment; Patients; Pharyngeal structure; Physiology; Plastic Surgical Procedures; Porosity; Pre-Clinical Model; Procedures; Reporting; Research Personnel; Scientific Advances and Accomplishments; Second Look Surgery; Speech; Speech Disorders; Stains; Surgical Management; Technology; Time; Tissue Stains; Tissues; Vascularization; Visualization software; Voice Disorders; absorption; care burden; clinical application; craniofacial; early childhood; imaging science; immunogenicity; implantation; improved; in vivo; inflammatory marker; innovation; manufacture; migration; minimally invasive; next generation; novel; particle; precision medicine; preclinical development; reconstruction; respiratory morbidity; retention rate; success; tissue regeneration; 3-Dimensional; Acute; Address; Advanced Development; Aerodigestive Tract; Affect; Aftercare; Anatomy; Animal Model; Biocompatible Materials; Biomedical Engineering; Blood Vessels; Calcium; Clinical; Collaborations; Collagen; Data; Dermis; Detection; Durapatite; Environment; Failure; Filler; Foreign-Body Reaction; Fostering; Functional disorder; Future; Gel; Goals; Growth; Hyaluronic Acid; Hydrogels; Immune; Implant; In Situ; Inflammation; Injectable; Injections; Light; Magnetic Resonance Imaging; Methodology; Methods; Microspheres; Modeling; Modernization; Molecular Conformation; Movement; Muscle; Operative Surgical Procedures; Oryctolagus cuniculus; Otolaryngology; Outcome; Outcome Assessment; Patients; Pharyngeal structure; Physiology; Plastic Surgical Procedures; Porosity; Pre-Clinical Model; Procedures; Reporting; Research Personnel; Scientific Advances and Accomplishments; Second Look Surgery; Speech; Speech Disorders; Stains; Surgical Management; Technology; Time; Tissue Stains; Tissues; Vascularization; Visualization software; Voice Disorders; absorption; care burden; clinical application; craniofacial; early childhood; imaging science; immunogenicity; implantation; improved; in vivo; inflammatory marker; innovation; manufacture; migration; minimally invasive; next generation; novel; particle; precision medicine; preclinical development; reconstruction; respiratory morbidity; retention rate; success; tissue regeneration

Synthetic hydrogels offer a promising platform for volumetric augmentation of the aerodigestive tract for precision medicine approaches. We propose that an ideal biomaterial platform for PPW augmentation to treat VPD would provide a durable tissue bulking effect, maintain implant configuration, and avoid FBR within a dynamic tissue environment. Specifically, Microporous Annealed Particle (MAP) hydrogels are an ideal material platform for the minimally invasive treatment of VPD. This novel biomaterial is a promising scientific advancement that has implications for improving VPD in patients with cleft and craniofacial conditions, particularly related to pharyngeal wall augmentation for managing VPD. There is a pressing need to utilize novel biomaterials and minimally invasive approaches to improve long-term outcomes for managing and resolving VPD. To address this need, we have developed a novel iteration of MAP hydrogel that is optimized for muscle implantation, tolerates dynamic movement, promotes excellent tissue integration, and provides persistent tissue bulk via 1:1 volume replacement with tissue de novo. Application of this unique biomaterial for PPW augmentation in an animal model will allow for novel analyses and new clinical applications for the MAP hydrogel. This proposal specifically aims to (1) quantify changes in pharyngeal wall anatomy in a rabbit model after pharyngeal wall augmentation and (2) identify the host-implant microenvironment required to achieve in situ tissue regeneration following optimized MAP gel pharyngeal wall augmentation.

合成水凝胶为体积增强提供了有前途的平台 精确医学方法的道。我们建议PPW的理想生物材料平台 增强治疗VPD将提供持久的组织散装效果，保持植入物 配置，并避免在动态组织环境中进行FBR。具体而言，微孔 退火颗粒（MAP）水凝胶是微创的理想材料平台 VPD的处理。这种新颖的生物材料是一个有前途的科学进步 在患有left裂和颅面疾病的患者中改善VPD的影响，特别是 与用于管理VPD的咽壁扩展有关。有迫切需要使用 新颖的生物材料和微创方法，以改善长期结局 管理和解决VPD。为了满足这一需求，我们开发了一种新颖的地图迭代 用于肌肉植入，耐受动态运动的水凝胶可促进 优秀的组织整合，并通过1：1替换为持续的组织散装 从头纸巾。在动物模型中，将这种独特的生物材料应用于PPW增强 将允许对MAP水凝胶进行新的分析和新的临床应用。这个建议 专门旨在（1）量化兔模型中咽壁解剖学的变化 咽壁扩展和（2）确定所需的宿主植入微环境 在优化的地图凝胶咽壁增强后，实现原位组织再生。