ISS: Plasmonic Bubble Enabled Nanoparticle Deposition under Micro-Gravity

ISS：微重力下等离子气泡实现纳米颗粒沉积

• 批准号: 2224307
• 负责人: Tengfei Luo
• 金额: $ 72.62万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2224307&HistoricalAwards=false
• 关键词: ISS; Plasmonic; Bubble; Enabled; Nanoparticle

Novel technologies that are simple and cost-effective for fabricating highly sensitive biosensors may significantly benefit a wide range of important applications, such as early detection of epidemic/pandemic infectious disease, cancers, and other biological agents. A major challenge for such detection is the low concentration of the target molecules. This project will leverage the fluid flow around a thermal bubble on a surface, concentrating and depositing the target molecules in the liquid sample, to enhance their detectability. The PI will perform microgravity experiments at the International Space Station to investigate the concentration/deposition processes, which will enable the development of improved sensing techniques for disease detection, cancer diagnosis and environmental monitoring. Given the potential transformative impacts for terrestrial applications, this project is aligned with the mission of CASIS to leverage space research to benefit life on earth. This research project will also educate and train graduate and undergraduate students from under-represented groups at Notre Dame. Through this project, the PI will cultivate a future workforce for the U.S. manufacturing and healthcare industries. The PI will also outreach to the local high schools and participate in local area science events to extend the outreach of this project. This project aims to understand the flow phenomena around a thermal bubble generated on a surface by a laser excitation. The flow pattern around the bubble can collect and eventually deposit colloidal particles in the liquid onto the surface. The overarching goal of this project is to understand the flow and deposition mechanism in order to control the deposition of suspended particles and thus enable new technologies for sensing applications. The PI will combine the microgravity experiments in the ISS and comparative terrestrial experiments complemented by multi-physics modeling to achieve this understanding. The micro-gravity environment in the ISS will provide a unique platform to unlock the fundamental mechanism of bubble nucleation, growth, and detachment. The lack of thermal convection in the ISS will allow the decoupling of the contribution of Marangoni effect from thermal convection effect to elucidate their roles in collecting colloidal particles and depositing them on the surface. This research will improve the understanding of the fundamental opto-thermal-fluidic mechanism of the thermal bubble deposition process, which will contribute to advancing the fields of nanoscale interactions, thermofluids and biosensing. This research project will also educate and train graduate and undergraduate students from under-represented groups at Notre Dame. Through this project, the PI will cultivate a future workforce for the U.S. manufacturing and healthcare industries. The PI will also outreach to the local high schools and participate in local area science events to extend the outreach of this project.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

用于制造高灵敏度生物传感器的简单且具有成本效益的新技术可能会显着有利于广泛的重要应用，例如流行病/大流行性传染病、癌症和其他生物制剂的早期检测。这种检测的主要挑战是目标分子浓度低。该项目将利用表面热气泡周围的流体流动，浓缩并沉积液体样品中的目标分子，以增强其可检测性。该项目负责人将在国际空间站进行微重力实验，以研究浓度/沉积过程，这将有助于开发用于疾病检测、癌症诊断和环境监测的改进传感技术。考虑到对地面应用的潜在变革性影响，该项目与 CASIS 的使命相一致，即利用空间研究造福地球上的生命。该研究项目还将教育和培训圣母大学代表性不足群体的研究生和本科生。通过这个项目，PI 将为美国制造业和医疗保健行业培养未来的劳动力。 PI 还将推广到当地高中并参加当地的科学活动，以扩大该项目的推广范围。该项目旨在了解激光激发在表面上产生的热气泡周围的流动现象。气泡周围的流动模式可以收集并最终将液体中的胶体颗粒沉积到表面上。该项目的总体目标是了解流动和沉积机制，以控制悬浮颗粒的沉积，从而实现传感应用的新技术。 PI 将结合国际空间站的微重力实验和地面比较实验，并辅以多物理模型来实现这一认识。国际空间站的微重力环境将提供一个独特的平台来解开气泡成核、生长和脱离的基本机制。国际空间站中缺乏热对流将使马兰戈尼效应与热对流效应的贡献分离，以阐明它们在收集胶体颗粒并将其沉积在表面上的作用。这项研究将增进对热气泡沉积过程的基本光热流体机制的理解，这将有助于推进纳米级相互作用、热流体和生物传感领域的发展。该研究项目还将教育和培训圣母大学代表性不足群体的研究生和本科生。通过这个项目，PI 将为美国制造业和医疗保健行业培养未来的劳动力。 PI 还将深入当地高中并参加当地科学活动，以扩大该项目的影响范围。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Analytical model of optical force on supercavitating plasmonic nanoparticles

超空泡等离子体纳米颗粒的光学力分析模型

• DOI: 10.1364/oe.491699
• 发表时间: 2023-06
• 期刊: Optics Express
• 影响因子: 3.8
• 作者: Mandal, Amartya;Lee, Eungkyu;Luo, Tengfei
• 通讯作者: Luo, Tengfei