I-Corps: Non-invasive, touch-based, natural sweat glucose sensor

I-Corps：非侵入式、触摸式、自然汗液葡萄糖传感器

• 批准号: 2233076
• 负责人: Joseph Wang
• 金额: $ 5万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2233076&HistoricalAwards=false
• 关键词: Corps; Non; invasive; touch; based

The broader impact/commercial potential of this I-Corps project is the development of a glucose sensor for diabetes patients. Diabetes mellitus impacts over 37.3 million people within the United States and 422 million people worldwide. All type 1 and most type 2 diabetes patients need frequent glucose testing to prevent life-threatening hyper/hypoglycemia, ketoacidosis, and long-term complications due to mismanaged glucose levels. Existing glucose sensors include capillary-blood fingersticks and subdermal continuous glucose monitors (CGM). Currently, over 95% of diabetes patients still use finger-pricking glucometers as their main glucose monitoring method, which is painful, messy, inconvenient, and creates social barriers. This technology provides a pain-free, convenient, and accessible sensing technology with discreet usage that helps diabetes patients understand their health status without the physical, social and financial burdens of CGM and fingersticks. With improved user compliance, this technology can collect data for personalized lifestyle training and personalized guiding services for better diet and diabetes management, and potentially improve the life quality of diabetes patients while reducing their healthcare costs.This I-Corps project is based on the development of a completely non-invasive, touch-based glucose sensor for spot glucose checking for diabetes patients. Unlike previous non-invasive glucose sensors that rely on unreliable near-infrared light or radio-frequency dielectric spectroscopy, this technology is based on FDA-approved electrochemical enzymatic glucose sensing which is highly selective and accurate. Instead of using fingertip capillary blood as the sensing biofluid, this sensor design allows the direct measurement of glucose within the constantly available passive perspiration from the fingertips. The technology allows users to obtain a sweat glucose reading by placing their fingers directly onto the sensor surface, where the natural fingertip sweat reacts readily with the sensor to produce an amperometric signal. With a first-time personalized calibration, the user is able to convert their sweat glucose signal to their blood glucose level with high accuracy. Thus, touch-based, non-invasive and reliable glucose sensing can be achieved.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是为糖尿病患者开发葡萄糖传感器。糖尿病会影响美国境内3730万人，全球4.22亿人口。所有类型1和大多数2型糖尿病患者都需要频繁的葡萄糖测试，以防止威胁生命的高血糖症，酮症酸中毒和长期并发症，这是由于葡萄糖水平不善而引起的。现有的葡萄糖传感器包括毛细血管血清指尖和下葡萄糖监测器（CGM）。目前，超过95％的糖尿病患者仍使用指尖的葡萄糖作为其主要葡萄糖监测方法，这是痛苦，凌乱，不便，并造成了社交障碍。这项技术提供了一种谨慎使用的无痛，方便且可访问的传感技术，可帮助糖尿病患者了解其健康状况，而无需CGM和Fingersticks的身体，社会和经济负担。通过改进的用户合规性，该技术可以收集数据，以进行个性化的生活方式培训和个性化指导服务，以更好地饮食和糖尿病管理，并有可能改善糖尿病患者的生活质量，同时降低其医疗保健成本。针对糖尿病患者的斑点葡萄糖检查完全无创的，基于触摸的葡萄糖传感器。与以前依赖于不可靠的近红外光或射频介电光谱的非侵入性葡萄糖传感器不同，该技术基于FDA批准的电化学酶促葡萄糖感测，具有高度选择性和准确性。该传感器设计不用用指尖毛细血管作为传感生物流体，而是可以直接测量从指尖持续可用的被动汗水中的葡萄糖。该技术使用户可以通过将手指直接放在传感器表面来获得汗水读数，在该表面上，自然指尖汗液可以轻松地与传感器反应以产生安培信号。通过首次个性化校准，用户可以将其汗水信号转换为血糖水平，以高精度。因此，可以实现基于触摸的，非侵入性和可靠的葡萄糖感知。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响评估标准，被认为值得通过评估来获得支持。