I-Corps: Non-invasive Indirect Calorimetry using Transdermal Optical Sensors for Diagnosis and Treatment of Metabolic Diseases

I-Corps：使用透皮光学传感器进行非侵入性间接量热法诊断和治疗代谢性疾病

• 批准号: 2324768
• 负责人: Ryan Buckley
• 金额: $ 5万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2324768&HistoricalAwards=false
• 关键词: Corps; Non; invasive; Indirect; Calorimetry

The broader impact/commercial potential of this I-Corps project is the development of an optical sensor that measures calories burned in real time. The proposed technology addresses the need for physicians and dieticians to accurately map a patient’s metabolic rate, which may provide information to assist in guiding proper nutrition and significantly reduce costs in seriously ill patients. In addition, professional athletes and others in the fitness industry may utilize such a technology to further develop and track their performance, providing crucial information to their coaches and sports medicine personnel. Current standard technologies, such as the metabolic cart, are large, cost-prohibitive ($50K), and require intensive training and personnel for operation. As an inexpensive alternative, clinicians rely on crude calculations and daily weight measurements to guide patient nutrition. These predictive equations are often not accurate and are non-inclusive, only applying to a subset of the population. Dietitians struggle with making estimates for a variety of patients, especially for premature infants and patients that are obese, undergoing liver transplant surgeries, or suffering from thyroid problems. Accurate metabolic information from the proposed device may significantly increase quality of care, reduce readmission rates, length of stay, and complications, and contribute to reduced costs and positive healthcare outcomes.This I-Corps project is based on the development of an optical sensor that evaluates peculiar gas analyte concentrations in the bloodstream to quantify the end-user’s metabolic rate. The goal is to implement the metabolism sensor as a wearable device to measure calorie output from a patient’s extremity (finger or ear). The metabolic rate sensor utilizes a transdermal or transcutaneous, non-invasive optical sensor that measures carbon dioxide (CO2) and oxygen (O2) levels in the blood. The ratio of incident light to collected light through tissue will provide the data needed to calculate the patient’s energy expenditure. As caloric fuel is burned in the body in the presence of O2, CO2 is produced before being exhaled. The sensor system employs low-cost light emitting diodes (LEDs) and photodiodes to measure the absorption and scattering of light at wavelengths specific to spectral markers of O2 and CO2. A proprietary algorithm adopted from the Weir equation estimates the number of calories burned in real time from continuous spectral measurement.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是开发一种实时测量卡路里消耗的光学传感器。所提出的技术满足了医生和营养师准确绘制患者代谢率的需求，这可以为患者提供信息。帮助指导重病患者适当的营养并显着降低费用。此外，职业运动员和健身行业的其他人可以利用这种技术来进一步发展和跟踪他们的表现，为他们的教练和运动医学人员提供重要信息。标准技术，例如代谢车，是体积大、成本高昂（5 万美元），并且需要密集的培训和操作人员作为一种廉价的替代方案，依靠粗略计算和每日体重测量来指导患者营养。仅适用于一小部分人群，营养师很难对各种患者进行估计，特别是对于早产儿和肥胖、接受肝移植手术或患有甲状腺问题的患者，所提出的设备的准确代谢信息可能会显着增加。提高质量护理，减少再入院率、住院时间和并发症，并有助于降低成本和积极的医疗保健结果。这个 I-Corps 项目基于光学传感器的开发，该传感器可评估血液中特殊的气体分析物浓度，以量化最终的结果-用户的代谢率。目标是将代谢传感器实现为可穿戴设备，以测量患者四肢（手指或耳朵）的卡路里输出。代谢率传感器利用经皮或经皮的非侵入性光学传感器进行测量。血液中二氧化碳 (CO2) 和氧气 (O2) 的水平将提供计算患者能量消耗所需的数据，因为热量燃料在氧气存在的情况下在体内燃烧。 ，二氧化碳在呼出之前产生。传感器系统采用低成本发光二极管 (LED) 和光电二极管来测量 O2 和 CO2 光谱标记特定波长的光吸收和散射。采用威尔方程估算通过连续光谱测量实时燃烧的卡路里数。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。