I-Corps: Non-invasive, multimode, hand-held technology for wound assessment

I-Corps：用于伤口评估的非侵入性、多模式、手持式技术

• 批准号: 2223456
• 负责人: Kouhyar Tavakolian
• 金额: $ 5万
• 依托单位: University of North Dakota Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2223456&HistoricalAwards=false
• 关键词: Corps; Non; invasive; multimode; hand

The broader impact/commercial potential of this I-Corps project is the development of a multimodal optical imaging system that quantitatively measures tissue biomarkers to characterize healing in diabetic wounds. Diabetic wounds in the US affect more than eight million patients annually with an estimated economic burden of around $30 billion. There is an unmet need for comprehensive imaging tools that can non-invasively measure multiple biomarkers, elucidate underlying tissue changes in diabetic wounds, and provide anatomical and functional information for individualized therapy. In addition, there is a need for objective wound assessment tools to furnish clinicians and caregivers with fast and quantitative methods of determining wound healing/nonhealing status. The proposed device has the potential to assess the risk of developing ulcers and to grade the status of an ulcer as well as to quantify several biomarkers to help guide treatment. Additionally, this technology may be applied to not only diabetic foot ulcers but also burn wounds, surgical wounds, pressure ulcers, and even amputation sites. The benefit may impact wound clinics, home health institutions, and long-term care facilities. This I-Corps project is based on the development of a non-invasive, multimodal, hand-held technology that combines thermal, reflectance, and fluorescence imaging to provide in vivo evaluation of tissue metabolic state, tissue oxygenation, vasculature, and temperature indices. The proposed technology may be used to provide treatment plans that can be adjusted and documented in a patient’s electronic medical record to inform decision-making. Monitoring of biomarkers may give clinicians early indication of complications during wound healing, leading to clearer and more effective interventions or changes in the wound care regime. There have been technological advances within the field of wound care. However, most monitoring technologies focus on a single biomarker. The proposed technology aims to fill in the gaps by combining the measurements of several biomarkers to give a more complete assessment of a wound. The combination of biomarkers plus recent advances in LED and camera technology have allowed for a multi-modal device to now be possible.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

对此的更广泛的影响/佣金是量化Uressue生物标志物在糖尿病伤口中的愈合为确定伤口愈合状态的快速和定量方法提供诊所的工具。不适用于糖尿病足溃疡，但还适用于伤口，手术伤口，溃疡，甚至截肢部位。一种非侵入性，多模式，手持技术的热和荧光cence成像，以提供组织代谢状态的体内评估，可以使用支撑技术的计划，可以在患者的电气中进行调整和记录，也可以在患者的电气中进行调整和记录。生物标志物可以在伤口愈合期间进行汇编，导致更清晰的E干预措施或伤口护理状况的变化。几种生物标志物的测量可以提供更多的生物标志物以及LED和摄像机技术的最新进展，而HABE现在可以使用CE。这一奖项反映了NSF'SF'Stututory Mission，并获得了值得支持的支持的支持，值得支持。基金会的智力优点和更广泛的影响审查标准。