Characterization of DNA-Linked Nanoparticle Networks for Advanced Genetic Testing

用于高级基因测试的 DNA 连接纳米颗粒网络的表征

• 批准号: 0503891
• 负责人: Joseph Wang
• 金额: $ 10.6万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-11-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0503891&HistoricalAwards=false
• 关键词: Characterization; DNA; Linked; Nanoparticle; Networks

Professor Joseph Wang of New Mexico State University is supported by the Analytical and Surface Chemistry Program to study nanoparticle-biopolymer assemblies for use as sensors. In particular, DNA hybridization events will be detected electrically on gold nanoparticles, with eventual applications in biodiagnostics and biodetection. New assays that couple multiple amplification pathways and an effective magnetic separation will allow for increased selectivity and sensitivity in the sensors. A new electrochemical coding technology will be developed for the simultaneous detection of multiple DNA targets. These projects will be combined on microfluidic device platforms. The ability to miniaturize complex chemical functions to achieve lab-on-a-chip is a goal of nanotechnology. In addition, this work can be related to biowarfare detection and thus has implications for national security.

新墨西哥州立大学的约瑟夫·王（Joseph Wang）教授得到了分析和表面化学计划的支持，以研究纳米颗粒 - 聚合物组件作为传感器。 特别是，将在金纳米颗粒上进行电气检测DNA杂交事件，并最终应用于生物诊断和生物调节。 夫妇多个扩增途径和有效磁分离的新测定将使传感器的选择性和灵敏度提高。 将开发一种新的电化学编码技术，以同时检测多个DNA靶标。 这些项目将在微流体设备平台上合并。 小型化学功能实现实验室芯片的能力是纳米技术的目标。 此外，这项工作可能与BiowArfare检测有关，因此对国家安全有影响。