Collaborative Research: Smart Dental Implant System for Ambulatory Dental Care

合作研究：用于门诊牙科护理的智能种植牙系统

• 批准号: 2225681
• 负责人: Albert Kim
• 金额: $ 25万
• 依托单位: Temple University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2225681&HistoricalAwards=false
• 关键词: Collaborative; Research; Smart; Dental; Implant

Every year, approximately 5 million implants are placed to replace missing teeth in the United States. Although the dental implant practice shows initial high success rates, many studies reported high occurrences of peri-implant diseases, up to 50% after 10 years of installation. These peri-implant diseases can potentially lead to patient discomfort, painful and costly surgical replacement of failed implants, and even the overall oral health breakdown. In particular, the geriatric population, smokers, or patients with a history of chronic periodontitis or diabetes were more vulnerable to peri-implant diseases. A significant body of studies indicates that the root causes of peri-implant disease are the accumulation of dental plaque at the soft tissue-implant interface and the subsequent local inflammation. Today, numerous antimicrobial agents are available, potentially reducing bacterial activity on the dental crown surface. However, most of these agents may not be appropriate for long-term use because these may disrupt ecological microbiota and induce drug resistance over time. In addition, antimicrobial coating surfaces have not been a great success due to the gradual loss of therapeutic agents into the surrounding environment. As such, the overall objective of this project is to build a practical strategy to prevent peri-implant disease by enhancing the immunity of peripheral soft tissue against bacterial infection. Furthermore, the project integrates the research with educational venues by mentoring graduate and undergraduate students, including underrepresented minorities and female students, developing interdisciplinary curricula to bridge the gap between engineering and biomedical research.The project leverages cross-cutting innovations spanning engineering and dental medicine to create an ambulatory dental care platform, a human oral motion-powered Smart Dental Implant (SDI) system. The SDI system enables in situ, highly effective, and targeted low-level light therapy in proximity to disease-prone areas. The SDI system represents a significant opportunity to improve the prevention of peri-implant disease. This project 1) elucidates the unprecedented potential of human oral biomechanical energy harvesting as a reliable power source, 2) understands the underlying mechanism of the photon-cell-microbe interaction in the new mode of near-contact low-level light therapy, and 3) validates the SDI system using a clinically relevant animal model of peri-implantitis. The outcome of this award will provide new perspectives on preventing and controlling the onset of peri-implant diseases. In addition, a successful demonstration of the energy harvesting technology will simultaneously extend the range of applicability in any field requiring near-zero power application. Finally, a similar concept can also be replicated in other microbially induced inflammations, such as skin wound healing and sustaining orthopedic implants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

每年，在美国，大约有500万个植入物可以替换缺失的牙齿。尽管牙科植入物的最初成功率显示出最初的成功率，但许多研究报告说，植入物疾病的发生率很高，安装10年后高达50％。这些种植体疾病可能会导致患者不适，疼痛且昂贵的外科手术替代植入物，甚至是整体口腔健康崩溃。特别是，患有慢性牙周炎或糖尿病病史的老年人群，吸烟者或患者更容易受到植入植入术的疾病。大量研究表明，植入物疾病的根本原因是在软组织植入物界面和随后的局部炎症处的牙菌斑积累。如今，有许多抗菌剂可用，可能会降低牙冠表面上的细菌活性。但是，这些药物中的大多数可能不适合长期使用，因为这些药物可能会破坏生态菌群并随着时间的推移诱导耐药性。此外，由于治疗剂逐渐损失到周围环境中，抗菌涂层表面并没有取得巨大的成功。因此，该项目的总体目的是建立一种实用策略，以通过增强外周软组织对细菌感染的免疫力来预防植入植物疾病。 Furthermore, the project integrates the research with educational venues by mentoring graduate and undergraduate students, including underrepresented minorities and female students, developing interdisciplinary curricula to bridge the gap between engineering and biomedical research.The project leverages cross-cutting innovations spanning engineering and dental medicine to create an ambulatory dental care platform, a human oral motion-powered Smart Dental Implant (SDI) system. SDI系统可以原位，高效且有针对性的低水平光疗法，可在易于疾病的地区附近。 SDI系统代表了改善预防植入植物疾病的重要机会。该项目1）阐明了人类口服生物力学收获作为可靠的电源的前所未有的潜力，2）了解在新的接近接触式低水平光疗法的新模式下，光子细胞 - 微生物互动的基本机制，以及3）使用临床上相关的动物模型的SDI系统验证SDI系统。该奖项的结果将为防止和控制植入物疾病的发作提供新的观点。此外，成功的演示能量收集技术将同时扩展任何需要接近零功率应用的领域的适用性范围。最后，类似的概念也可以在其他微生物诱发的炎症中复制，例如皮肤伤口愈合和持续的骨科植入物。该奖项反映了NSF的法定任务，并认为值得通过基金会的智力优点和更广泛的影响审查标准通过评估来获得支持。