CAREER: Acousto-Bioelectronics

职业：声学生物电子学

基本信息

批准号：
2245090
负责人：
Albert Kim
金额：
$ 50万
依托单位：
University of South Florida
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-10-01 至 2027-08-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2245090&HistoricalAwards=false
关键词：
CAREER Acousto Bioelectronics

项目摘要

This CAREER project is a part of a global effort to conquer cancer, the second leading cause of death. Despite the enormous investments in research and development, there have been scant clinical successes as a viable cancer therapy. Recent advancements in cancer therapy have resulted in the emergence of implanted medical devices (IMDs) into feasible medicines, owing to their capacity to localize treatments, albeit limited in numbers. However, currently available IMDs-mediated cancer treatments are often confined to a single, non-replenishable administration per therapy. These limitations, along with a number of risks such as painful surgery, infection risk in the catheter, and device failure, have generally hampered the usage of IMDs in cancer treatment. More importantly, cancer cannot be effectively managed with a single therapeutic approach due to its complex, diverse, and heterogeneous nature. As such, this CAREER project investigates a versatile engineering solution in the form of an acoustically driven implantable microsystem that provides a tailored combination of multimodal cancer therapeutics: oxygen, chemotherapy drugs, and light. Combined, this project aims to establish the field of ‘Acousto-Bioelectronics’ that spurs new theory and understanding for the next generation of IMDs. Furthermore, the project integrates the research with educational venues by mentoring graduate and undergraduate students, with a particular emphasis on the underrepresented minorities and female students, developing interdisciplinary curricula, and creating pedagogical resources ranging from fundamental theory to hands-on activities.While IMDs are transforming modern healthcare, they are unable to cure cancer at the moment due to their short lifetime. This is compounded by the fact that many cancers can relapse or spread metastatically. The overarching goal of this CAREER project is to leverage cross-cutting innovations from the domain of engineering and healthcare fields to create an ultrasonically-powered implantable microsystem that enables a tailored combination of multimodal cancer therapies. This study (1) elucidates the untapped potential of Platonic solid structures for a highly efficient omnidirectional ultrasonic powering scheme for IMDs, utilizing a unique 3D-printable barium titanate ultrasonic receiver. (2) Providing adequate power via ultrasound, the microsystem enables the in-situ generation of oxygen, cisplatin, and light through controlled electrochemical and photochemical processes. It is hence called Oxygen Enhanced Chemo-Photodynamic Therapy. (3) The microsystem can potentially realize clinically-proven superadditive anticancer effect – stronger than any single therapy or theoretical combination. The microsystem-mediated multimodal cancer therapy would be validated through a comprehensive evaluation by employing clinically relevant models (in vitro and in vivo cancer models). The outcome of this project justifies the development of the IMD-mediated multimodal cancer therapy that will potentially help patients suffering from aggressive and fatal cancer types with limited treatment alternatives.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个职业项目是征服癌症的全球努力的一部分，这是死亡的第二大原因。尽管在研发上进行了巨大的投资，但作为一种可行的癌症治疗，临床成功取得了很大的成功。癌症疗法的最新进展导致植入医疗设备（IMD）的出现在可行的药物中，因为它们可以定位治疗，尽管数量有限。但是，目前可用的IMDS介导的癌症治疗通常仅限于每种疗法的单一不可再生性给药。这些局限性以及许多风险，例如疼痛手术，导管中的感染风险以及装置故障，通常会阻碍IMD在癌症治疗中的使用。更重要的是，由于其复杂，潜水和异质性，癌症无法通过一种治疗方法有效地进行管理。因此，该职业项目以声学驱动的可植入的微系统的形式研究了一种多功能的工程解决方案，该解决方案提供了多模式癌疗法的量身定制组合：氧气，化学疗法药物和光。该项目结合起来，旨在建立“声音电子学”的领域，该领域激发了下一代IMD的新理论和理解。此外，该项目通过心理毕业生和本科生将研究与教育场所融合在一起，特别着重于代表性不足的少数群体和女学生，开发跨学科课程，以及创造教学资源以及创造从基本理论到动手的活动的教学资源。许多癌症可以转移或传播的事实使这一事实更加复杂。该职业项目的总体目标是利用工程和医疗保健领域领域的跨裁切创新，创建一个超声驱动的植入式微型系统，以实现多模式癌疗法的量身定制组合。这项研究（1）阐明了使用独特的3D打印钛酸钛钛酸盐超声接收器，为IMD的高效全向超声动力方案提供了柏拉图固体结构的未开发潜力。（2）通过超声提供足够的功率，微系统通过受控的电化学和光化学过程实现了氧，顺铂和光的原位生成。因此，它被称为氧气增强的化学化学疗法。（3）微型系统可以潜在地实现临床证实的超增强抗癌作用 - 比任何一种疗法或理论组合都要强。微系统介导的多模式癌症治疗将通过使用临床相关模型（体外和体内癌）进行全面评估来验证。模型）。该项目的结果证明了IMD介导的多模式癌疗法的发展，该疗法将有可能帮助患有侵略性和致命癌症类型的患者具有有限的治疗方法。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛影响的审查标准来通过评估来获得的支持。