CNS Core: Small: Reconfigurable Intrabody Network for Therapeutics (RIBNeT)

CNS 核心：小型：用于治疗的可重构体内网络 (RIBNeT)

基本信息

批准号：
2129659
负责人：
Albert Kim
金额：
$ 50万
依托单位：
Temple University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-10-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2129659&HistoricalAwards=false
关键词：
CNS Core Small Reconfigurable Intrabody

项目摘要

Chronic diseases are on a rapid rise throughout the world due to the growing aging population and increasing air, water, and food pollution in developing countries. Recently, emerging implantable and wearable medical devices have led to new insights in continuous monitoring and automated diagnosis for chronic diseases. To effectively manage chronic diseases through medical devices, this research project explores the design of robust and reconfigurable intrabody therapeutic networks that harvest their own energy. We henceforth call it Reconfigurable Intrabody Network for Therapeutics or RIBNeT. Since the medical needs dictate the location and functions of nodes, the RIBNeT coordinates the operation of two types of nodes in physically separate portions of the body - the intrabody (energy) harvesting nodes and the intrabody therapeutic nodes. The key intellectual merit of the proposal is in exploring a radically different landscape of energy transfer and data communication for RIBNeT from the perspective of building and operating small therapeutic networks as dictated by medical needs. Based on the magnetic induction communications (MIC) technology that works well for the intrabody environment, the energy harvesting and transfer throughout the body are modeled and tested. A single on-body node (OBN) is augmented for energy availability inside the body to enable sustained long-term operation of RIBNeTs. The project also explores the challenges posed by OBN to the RIBNeT and devise ways of addressing them. In particular, it designs lightweight mechanisms to monitor and collaboratively optimize the energy delivery via internal harvesting and OBN, and explores ways of making the operation robust in the face of OBN removals. In order to minimize energy use, RIBNeT maximizes opportunities for the nodes to sleep and minimizes need for inter-node coordination, while still allowing for emergency transmissions and mitigation of interference between various transmissions. In order to handle combined energy transfer and communications, the project explores the design of multi-segment antennas and a thin film-based MEMS energy harvester integrated into antennas. We build circuit boards for integrated energy transfer and communications and test them using ex vivo animal tissue and human subjects. Overall, the project is expected to pave the way for the commercial development of highly capable reconfigurable intrabody networks for therapeutics (RIBNeT). This project will also integrate the scientific findings and discoveries in education for students across disciplines (Computer Science, Electrical Engineering, and Biology).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

由于人口老龄化以及发展中国家的空气，水和粮食污染的增加，慢性疾病在全球范围内迅速增长。最近，新兴的可植入和可穿戴的医疗设备导致了对慢性疾病的持续监测和自动诊断的新见解。为了通过医疗设备有效地管理慢性疾病，该研究项目探讨了收获自身能量的可靠和可重新配置的内部内部治疗网络的设计。因此，我们称其为治疗或RIBNET的可重构内置网络。由于医疗需求决定了节点的位置和功能，因此RibNet会在身体的物理分离部分中协调两种类型的节点的操作 - 内部（能量）收集节点和内部治疗性淋巴结。该提案的关键知识优点是从建筑物和运营医疗需求决定的小型治疗网络的角度探索RIBNET的截然不同的环境和数据通信。基于适合内部迹象环境的磁感应通信（MIC）技术，对整个身体的能量收集和转移进行了建模和测试。增加了一个体内节点（OBN），以增加体内的能量可用性，以实现肋骨的持续长期操作。该项目还探讨了OBN对Ribnet构成的挑战，并设计了解决方案的方法。特别是，它设计了轻巧的机制来监视和协作通过内部收获和OBN来优化能量传递，并探索面对OBN去除时使操作稳健的方法。为了最大程度地减少能源的使用，RibNet最大程度地利用节点入睡并最大程度地减少节点间协调的需求，同时仍允许紧急传播和缓解各种传播之间的干扰。为了处理合并的能量传输和通信，该项目探讨了整合到天线中的多段天线和基于薄膜的MEMS能量收割机的设计。我们建立用于整合能量传输和通信的电路板，并使用离体动物组织和人类受试者进行测试。总体而言，该项目有望为高度可重新配置的用于治疗剂（RIBNET）的可重新配置的内置象征网络的商业开发铺平道路。该项目还将整合跨学科的学生（计算机科学，电气工程和生物学）的教育中的科学发现和发现。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响来评估的评估值得支持的。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Performance Evaluation of Magnetic Resonance Coupling Method for Intra-Body Network (IBNet)

DOI：
10.1109/tbme.2021.3130408
发表时间：
2022-06-01
期刊：
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
影响因子：
4.6
作者：
Islam，Sayemul;Gulati，Rajpreet Kaur;Kim，Albert
通讯作者：
Kim，Albert

MagLoc: A magnetic induction based localization scheme for fresh food logistics

DOI：
10.1016/j.iot.2022.100552
发表时间：
2022-06
期刊：
Internet Things
影响因子：
0
作者：
Amitangshu Pal;K. Kant
通讯作者：
Amitangshu Pal;K. Kant

Characterization of Magnetic Communication Through Human Body

DOI：
10.1109/ccnc49033.2022.9700669
发表时间：
2022-01
期刊：
2022 IEEE 19th Annual Consumer Communications & Networking Conference (CCNC)
影响因子：
0
作者：
R. K. Gulati;Sayemul Islam;Amitangshu Pal;K. Kant;Albert Kim
通讯作者：
R. K. Gulati;Sayemul Islam;Amitangshu Pal;K. Kant;Albert Kim

Ultrasonic vs. Magnetic Resonance Communication for Mixed Wearable and Implanted Devices

混合可穿戴设备和植入设备的超声波与磁共振通信