MRI: Acquisition of High Frequency Electron Paramagnetic Spectrometer – cutting edge tool for modern research

MRI：购买高频电子顺磁能谱仪 — 现代研究的尖端工具

• 批准号: 2117638
• 负责人: Slawomir Lomnicki
• 金额: $ 146.28万
• 依托单位: Louisiana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117638&HistoricalAwards=false
• 关键词: MRI; Acquisition; Frequency; Electron; Paramagnetic

This award enables the acquisition of the most modern instrumentation (high frequency/high field electron paramagnetic spectrometer) to study structure of compounds that contain unpaired electrons. Such molecules are called “paramagnetic” and have critical functions in living organisms and in the environment. This instrument will provide a cutting edge tool for studies in medicine and biology (new drug development, understanding of protein activity and interactions, and development of new molecules used for disease diagnostics), informatics and engineering (development of new class of memory chips, green energy materials) and will allow for significant technological jump that enables advanced studies of such systems. Studies of paramagnetic compounds have been hampered due to poor resolution of existing technology and this technique has not traditionally been used as a common tool for research due to its technological limitations and low availability. This instrument will not only add a completely new dimension to the research capabilities for many regional and national researchers, but also provide an essential learning tool for a new generation of scientists. Training will be provided to students and postdoctoral associates nationwide through an open house program advertised at research institutions throughout the country.The award seeks to purchase the Bruker ELEXYS E780, the first commercially manufactured high frequency/high field electron paramagnetic spectrometer in the United States, operating at 263 GHz. This would be the second instrument operating above 250 GHz; and the only high frequency instrument with electron-nuclear resonance capabilities. The ELEXYS E780 can perform experiments at both continuous wave and pulse wave mode, with electron-nuclear double resonance and electron-nuclear-nuclear resonance techniques and at temperatures down to 4 K. As a result, a significant increase in sensitivity and resolution of the spin orientation in the magnetic field can be achieved, which provides detailed structural information of the paramagnetic center. Detailed information regarding the nuclear distances from the paramagnetic centers and high spectral resolution can be achieved in solids, gases, liquids, cells, and in vivo. Projects that will immediately benefit from the acquisition of this instrument include research to understand changes in mitochondria function in diseases; photosystem II operation and development of man-made photosynthesis systems; conversion of biomass into valuable products; engineering of better polymers; development of new bioimaging molecules; and understanding the origin and fate of many environmental pollutants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项使我们能够购买最先进的仪器（高频/高场电子顺磁光谱仪）来研究含有不成对电子的化合物的结构，这些分子被称为“顺磁”，在生物体和环境仪器中具有关键功能。将为医学和生物学（新药开发、蛋白质活性和相互作用的理解以及用于疾病诊断的新分子的开发）、信息学和工程（新型存储芯片的开发、绿色能源）的研究提供尖端工具由于现有技术的分辨率较差，并且由于其技术限制，该技术传统上并未被用作研究的常用工具。该仪器不仅将为许多地区和国家研究人员的研究能力增加一个全新的维度，而且还为全国范围内的学生和博士后同事提供培训。在整个研究机构宣传的开放日计划该奖项旨在购买 Bruker ELEXYS E780，这是美国第一台商业化制造的高频/高场电子顺磁光谱仪，工作频率为 263 GHz。这将是第二台工作频率超过 250 GHz 的仪器，也是唯一的高频仪器。 ELEXYS E780 具有电子-核共振功能，可以在连续波和脉冲波模式下进行实验，具有电子-核双共振和电子-核-核共振技术。在低至 4 K 的温度下，可以显着提高磁场中自旋方向的灵敏度和分辨率，从而提供有关顺磁中心的核距离的详细信息。获得该仪器将立即受益的项目包括了解疾病中线粒体功能的变化和开发。人造光合作用系统；将生物质转化为更有价值的聚合物；开发新的生物成像分子；以及了解许多环境污染物的起源和归宿。该奖项反映了 NSF 的法定使命，并通过评估被认为值得支持。利用基金会的智力优势和更广泛的影响审查标准。