MRI: Acquisition of a High-Resolution Accurate-Mass Orbitrap LC-MS System at Montclair State University

MRI：在蒙特克莱尔州立大学购置高分辨率精确质量 Orbitrap LC-MS 系统

• 批准号: 2116596
• 负责人: Jinshan Gao
• 金额: $ 45万
• 依托单位: Montclair State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2116596&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Accurate; Mass

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Montclair State University is acquiring a benchtop high-resolution accurate-mass ultrahigh-pressure liquid chromatograph tandem mass spectrometry (UPLC-MS/MS) system with an orbitrap analyzer to support Dr. Jinshan Gao and colleagues Meiyin Wu, Nina Goodey, Yang Deng and David Rotella. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species in complex samples. An instrument with a liquid chromatograph provides additional structural identification power by separating mixtures of compounds before they reach the mass spectrometer. The tandem capabilities, which couples together two mass analyzers, increase the ability of the mass spectrometer to analyze chemical samples. The acquisition strengthens the research infrastructure at this Hispanic Serving Institution and regional area. The instrument broadens participation by involving diverse students with this modern analytical technique. It is also used by collaborators at the New Jersey Institute of Technology, Fairleigh Dickinson University and Rutgers University.The award of the UPLC-MS/MS (Ultra-high performance liquid chromatography/two dimensional mass spectrometry) system is aimed at enhancing research and education at all levels. It is especially useful for quantifying and characterizing glycan, proteins and glycoproteins as well as identifying polycyclic aromatic hydrocarbons, cyanotoxin, lipids and biopolymers. The instrumentation is also used for characterizing potential drug candidates and their metabolites and for the identification of and quantification of emerging contaminants and their transformation products in water and wastewater. The instrument also serves researchers characterizing genotoxic impurities in drug substances and other products.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具和化学研究工具计划的支持。蒙特克莱州立大学（Montclair State University）正在使用Orbitrap Analyzer购买台式高分辨率准确的质量超高压液相色谱串联量质谱法（UPLC-MS/MS）系统，以支持Jinshan Gao博士，并同意Meiyin wu，Meiyin Wu，Nina Goodey，Nina Goodey，Yang Deng和David David Rotella。通常，质谱法（MS）是用于识别和表征复杂样品中少量化学物种的关键分析方法之一。 具有液相色谱仪的仪器通过将化合物的混合物分离到质谱仪之前，从而提供了其他结构识别能力。串联功能将两个质量分析仪融在一起，提高了质谱仪分析化学样品的能力。收购加强了这个西班牙裔服务机构和地区地区的研究基础设施。该乐器通过让多样化的学生使用这种现代分析技术来扩大参与。新泽西理工学院，费尔利·迪金森大学和罗格斯大学的合作者还使用了它。它对于量化和表征聚糖，蛋白质和糖蛋白以及鉴定多环芳烃，氰毒素，脂质和生物聚合物特别有用。 该仪器还用于表征潜在的候选药物及其代谢产物，以及在水和废水中鉴定和定量新兴污染物及其转化产物。该工具还为研究人员提供了特征在于药物和其他产品中遗传毒性杂质的研究人员。该奖项反映了NSF的法定任务，并且使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估来支持。

项目成果

Cyclic sulfones from double conjugate addition of Rongalite

• DOI: 10.1080/00397911.2023.2222316
• 发表时间: 2023-06
• 期刊: Synthetic Communications
• 影响因子: 2.1
• 作者: Melina Goga;Haonan Zong;Jazmine Prana;Rudolph Michel;Antonia Muro;Elana Rubin;Janet Brenya;M. Bebbington